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Dynamic and equilibrium swelling studies: crosslinked pH sensitive methyl methacrylate-co-itaconic acid (MMA-co-IA) hydrogels

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Abstract

In the present work crosslinked methyl methacrylate-co-itaconic acid (MMA-co-IA) hydrogels were prepared by free radical copolymerization of methyl methacrylate (MMA) with itaconic acid (IA) using ethylene glycol dimethacrylate (EGDMA) and N, N methylene bisacrylamide (MBAAm) as crosslinkers and benzoyl peroxide as initiator. Prepared hydrogels were investigated for dynamic and equilibrium swelling studies. For swelling behaviour, effect of pH, monomeric compositions, degree of crosslinking and type of crosslinking agent were investigated. Swelling studies were performed in the USP phosphate buffer solutions of varying pH 1.2, 4.5, 5.5, 6.5 and 7.0. Results showed that swelling increased by increasing IA content in hydrogels structure. This may be due to the presence of more carboxylic groups available for ionization. Swelling was decreased with increase in crosslinking ratio owing to tighter hydrogel structure. Hydrogels were characterized by Fourier transform infrared (FTIR), and scanning electron microscope (SEM). Polymer-solvent interaction parameters (χ) of hydrogels were determined by using Flory–Rehner theory of equilibrium swelling values. The analysis of diffusion mechanism from gels using Peppas model showed that all monomeric compositions and degrees of crosslinking followed Fickian diffusion.

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References

  1. Peppas NA, Buri P, Leobandung W, Ichikawa H (1992) Eur J Pharm Biopharm 20:27–46

    Google Scholar 

  2. Brondsted H, Kopecek J (1992) pH-sensitive hydrogels. American Chemical society, Washington, DC, pp 285–305

    Google Scholar 

  3. Tomic SL, Suljovrujic EH, Filipovic JM (2006) Polym Bull 57:691–702

    Article  CAS  Google Scholar 

  4. Tomic SLJ, Micic MM, Filipovic JM, Suljovrujic EH (2007) Radiat Phys Chem 76:801–810

    Article  CAS  Google Scholar 

  5. Tomic SLJ, Micic MM, Filipovic JM, Suljovrujic EH (2007) Radiat Phys Chem 76:1390–1394

    Article  CAS  Google Scholar 

  6. Brondsted H, Kopecek J (1991) Biomat 12:584–592

    Article  CAS  Google Scholar 

  7. Peppas NA, Mikos AG (1986) Hydrogels in medicine and pharmacy, Vol 1. CRC Press, Boca Raton, FL

    Google Scholar 

  8. Ranjha NM, Doelker E (1999a) Saudi Pharm J 7:137–143

    CAS  Google Scholar 

  9. Ranjha NM, Doelker E (1999b) STP Pharm Sci 9(4):335–340

    CAS  Google Scholar 

  10. Ranjha NM, Doelker E (1999c) STP Pharm Sci 9(4):341–349

    CAS  Google Scholar 

  11. Peppas NA (1985) Pharm Acta Helv 60:110–111

    CAS  Google Scholar 

  12. Kare AR, Peppas NA (1995) Biomat 16:559–567

    Article  Google Scholar 

  13. Peppas NA, Barr-Howell BD (1987) Hydrogels in medicine and pharmacy. CRC Press, Boca Raton, p 27

    Google Scholar 

  14. Crank J (1975) In The mathematics of diffusin, 2nd edn. Oxford, Clarendon Press, p 244

    Google Scholar 

  15. Britton LN, Ashman RB, Aminabhavi TM, Cassidy PE (1988) J Chem Educ 65:368

    Article  CAS  Google Scholar 

  16. Chen KS, Ku Yuan YA, Lin HR, Yan TR, Sheu DC, Chen TM, Lin FH (2005) Mater Chem Phys 91:484–489

    Article  CAS  Google Scholar 

  17. Flory PJ (1953) Principles of Polymer Chemistry. Cornell University, Ithaca, NY

    Google Scholar 

  18. Xue W, Champ S, Huglin MB (2001) Polymer 42:3665

    Article  CAS  Google Scholar 

  19. Caykara T, Dogmus M, Kantogluo O (2004) J Polym Sci B Polym Phy 42(13):2586–2594

    Article  CAS  Google Scholar 

  20. Sen M, Yakar A (2005) Nucl Instrum Methods Phy Res B 234:226–234

    Article  CAS  Google Scholar 

  21. Moreau W, Merritt D, Moyer W, Hatzakis M, Johnson D, Pederson L (1979) J Vac Sci Technol 16:1989

    Article  CAS  Google Scholar 

  22. Soykan C, Erol I (2004) J Polym Res 11:53–63

    Article  CAS  Google Scholar 

  23. Siegel RA, Firestone BA (1988) Macromol 21:3254

    Article  CAS  Google Scholar 

  24. Karadag E (2002) Turk J Chem 26:863–875

    CAS  Google Scholar 

Download references

Acknowledgement

We thank the Ministry of Health, Government of Pakistan for funding this research project. We thank the Faculty of Pharmacy B.Z. University for providing laboratory facilities. Director Centralized Resource Laboratory, Department of Physics University of the Peshawar, and Centre of Excellence in Solid State Physics, University of the Punjab, Lahore for providing us the facility of SEM is also acknowledged.

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Authors and Affiliations

  1. Bahauddin Zakariya University Multan, Multan, Pakistan

    Jahanzeb Mudassir & Nazar Mohammad Ranjha

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  1. Jahanzeb Mudassir
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  2. Nazar Mohammad Ranjha
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Correspondence to Nazar Mohammad Ranjha.

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Mudassir, J., Ranjha, N.M. Dynamic and equilibrium swelling studies: crosslinked pH sensitive methyl methacrylate-co-itaconic acid (MMA-co-IA) hydrogels. J Polym Res 15, 195–203 (2008). https://doi.org/10.1007/s10965-007-9159-x

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  • DOI: https://doi.org/10.1007/s10965-007-9159-x

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