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A new biodegradable polymer: PEGylated chitosan-g-PEI possessing a hydroxyl group at the PEG end

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Abstract

The heterobifunctional polyethylene glycol (PEG) was synthesized by a facile and an efficient synthetic route. A new biodegradable graft copolymer of chitosan-g-PEI-g-PEG-OH possessing a hydroxyl group at the PEG chain end was prepared by the method of grafting reaction between chitosan, polyethylenimine (PEI) and heterobifunctional PEG for constructing amphiphilic copolymers. The amphiphilic and end-functionalized copolymer may have a potential utility in conjugating with targeting moieties for targetable gene or drug delivery.

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Acknowledgements

The authors are grateful for the financial support of 985 Foundation of Ministry of Education and Special Foundation for University Doctorial Subject of Ministry of Education (20060532022). Authors thank Professor Shuming Nie (Departments of Biomedical Engineering and Chemistry, Emory University and Georgia Institute of Technology, Atlanta) for the discussion and suggestion.

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Authors and Affiliations

  1. College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, People’s Republic of China

    Yundong Wu, Chengbin Liu, Xiangyun Zhao & Jiannan Xiang

  2. Biomedical Engineering Center, Hunan University, Changsha, 410082, People’s Republic of China

    Yundong Wu, Chengbin Liu, Xiangyun Zhao & Jiannan Xiang

  3. State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, 410082, People’s Republic of China

    Chengbin Liu & Jiannan Xiang

Authors
  1. Yundong Wu
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  2. Chengbin Liu
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  3. Xiangyun Zhao
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  4. Jiannan Xiang
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Correspondence to Chengbin Liu.

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Wu, Y., Liu, C., Zhao, X. et al. A new biodegradable polymer: PEGylated chitosan-g-PEI possessing a hydroxyl group at the PEG end. J Polym Res 15, 181–185 (2008). https://doi.org/10.1007/s10965-007-9157-z

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  • DOI: https://doi.org/10.1007/s10965-007-9157-z

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