Skip to main content
SpringerLink
Log in

Synthesis and Characterization of Stimuli-Responsive Poly(N-isopropylacrylamide-co-N-vinyl-2-pyrrolidone)

  • Published:
Journal of Polymer Research Aims and scope Submit manuscript

Abstract

Radical copolymerization of N-isopropylacrylamide (NIPA) with N-vinyl-2-pyrrolidone (VP) were carried out with 2,2′-azobisisobutyronitrile (AIBN) as an intiator in N,N′-dimethylformamide solution at 65°C under nitrogen atmosphere. Compositon of the copolymers synthesized in a wide range of monomer feed ratios were determined by FTIR and 1H (13C) NMR-DEPT-135 spectroscopy. The monomer reactivity ratios were determined by Fineman-Ross, Kelen-Tüdös and non-linear regression methods. It was observed that the studied monomer pair has some tendency to alternation in the chosen monomer feed ratios due to formation of intermolecular interaction through H-bonding and N → O = C coordination. The synthesized poly(NIPA-co-VP)s show temperature sensitivity (T s), higher glass-transiton temperature (T g ), thermal stability, polyelectrolyte and stimuli-responsive (temperature- and pH-sensitive) behavior and can be attributed to the class of bioengineering functional copolymers useful for application in various gene- and bioengineering processes, drug delivery systems and biomacromolecule conjugations.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Explore related subjects

Discover the latest articles, news and stories from top researchers in related subjects.

References

  1. J.-C. Leroux, E. Roux, D. Le Garrec, K. Hong and D. C. Drummond, J. Control. Release, 72, 71 (2001).

    Article  CAS  Google Scholar 

  2. M. Kurisawa, M. Yokoyama and T. Okano, J. Control. Release 69, 127 (2000).

    Article  CAS  Google Scholar 

  3. E. Kofukuta, Adv. Polym. Sci., 110, 167 (1993).

    Google Scholar 

  4. J.-P. Chen, M. -Sh. Hsu, J. Mol. Catal., B Enzym., 2, 233 (1997).

    Article  CAS  Google Scholar 

  5. T. Okano, Adv. Polym. Sci., 110, 179 (1993).

    Article  CAS  Google Scholar 

  6. W. Xue, S. Champ and M. B. Huglin, Polymer, 42, 2247 (2001).

    Article  CAS  Google Scholar 

  7. M. Miyajima, M. Yoshida, H. Sato, H. Omichi, R. Katakai and W. Higuchi, Eur. Polym. J., 30, 827 (1994).

    Article  CAS  Google Scholar 

  8. M. J. Snowden, D. Thomas and B. Vincent, Analytika 118, 1367 (1993).

    CAS  Google Scholar 

  9. G. E. Morris, B. Vincent and M. J. Snowden, J. Colloid Interface Sci. 190, 198 (1997).

    Article  CAS  Google Scholar 

  10. X. B. Ding, Z. H. Sun, W. C. Zhang, Y. X. Peng and G. X. Wan, J. Appl. Polym. Sci., 77, 2915 (2000).

    Article  CAS  Google Scholar 

  11. H. Ringsdorf, J. Venzmer and F. M. Vinnik, Macromolecules, 24, 1678 (1991).

    Article  CAS  Google Scholar 

  12. D. Umeno and M. Maeda, Anal. Sci., 13, 553 (1997).

    Article  Google Scholar 

  13. S. Dincer, V. Köseli, H. Kesim, Z. M. O. Rzaev and E. Piskin, Eur. Polym. J., 38, 2143 (2002).

    Article  CAS  Google Scholar 

  14. H. Kesim, Z. M. O. Rzaev, S. Dincer and E. Piskin, Polymer, 44, 2897 (2003).

    Article  CAS  Google Scholar 

  15. V. Köseli, Z. M. O. Rzaev, E. Piskin, J. Polym. Sci. A-1, Polym. Chem., 41, 1580 (2003).

    Article  CAS  Google Scholar 

  16. K. Otake, H. Inomata, M. Konno and S. Saita, Macromolecules, 23, 83 (1990).

    Article  Google Scholar 

  17. S. Hirotsu, Macromolecules, 25, 4445 (1992).

    Article  CAS  Google Scholar 

  18. C. Dong and A. S. Hoffman, J. Control. Release, 13, 21 (1990).

    Article  CAS  Google Scholar 

  19. A. Chilkoti, G. Chen, P. S. Stayton and A. S. Hoffman, Bioconjug. Chem., 5, 504 (1994).

    Article  CAS  Google Scholar 

  20. G. Chen and A. S. Hoffman, Macromol. Rapid Commun., 16, 175 (1995).

    Article  CAS  Google Scholar 

  21. A. Tuncel, D. Demirgöz, S. Patir and E. Piskin, J. Appl. Polym. Sci., 84, 2060 (2002).

    Article  CAS  Google Scholar 

  22. G. Bokias and D. Hourdert, Macromolecules, 33, 2929 (2000).

    Article  CAS  Google Scholar 

  23. G. Bokias and D. Hourdert, Polymer, 42, 6329 (2001).

    Article  CAS  Google Scholar 

  24. S. Dincer, A. Tuncel and E. Piskin, Macromol. Chem. Phys., 203, 1460 (2002).

    Article  CAS  Google Scholar 

  25. M. Türk, S. Dincer, G. I. Yulug, E. Piskin, J. Control Rel., 96, 325 (2004).

    Article  CAS  Google Scholar 

  26. V. Bulmuş, S. Patır, A. Tuncel and E. Piskin, J. Control. Release, 76, 265 (2001).

    Article  Google Scholar 

  27. H. F. Mark, N. M. Bikales, C. G. Overberger and G. Menges, Encyclopedia of Polymer Science and Engineering, Wiley-Inter- science, New York, 17, 1989, p. 198.

    Google Scholar 

  28. Y. E. Kirsh, Water Soluble Poly-N-vinylamides, Synthesis and Physicochemical Properties, Chichester, Wiley, 1998, p. 233.

    Google Scholar 

  29. M. B. Huglin and K. S. Khairou, Eur. Polym. J., 24, 239 (1988).

    Article  CAS  Google Scholar 

  30. A. S. Brar and R. Kumar, Polym. Int., 51, 519 (2002).

    Article  CAS  Google Scholar 

  31. N. Gatica, L. Gargallo and D. Radic, Polym. Int., 45, 285 (1998).

    Article  CAS  Google Scholar 

  32. N. Gatica, L. Gargallo and D. Radic, Eur. Polym. J., 38, 1371 (2002).

    Article  CAS  Google Scholar 

  33. L. Veron, M. Revol, B. Mandransd and T. Delair, J. Appl. Polym. Sci., 81, 3327 (2001).

    Article  CAS  Google Scholar 

  34. G. Georgiev, C. Konstantinov and V. Kabaivanov, Macromolecules, 25, 6302 (1992).

    Article  CAS  Google Scholar 

  35. L.-T. Ng, S. Jönsson, S. Swami and K. Lindgren, Polym. Int., 51, 1398 (2002).

    Article  CAS  Google Scholar 

  36. B. Reddy, R. Arshady and M. George, Eur. Polym. J., 21, 511, (1985).

    Article  CAS  Google Scholar 

  37. D. Radic and L. Gargallo, Macromolecules, 30, 817 (1997).

    Article  CAS  Google Scholar 

  38. G. Bauduin, B. Boutevin, M. Belbachir and R. Meghabar, Macromolecules, 28, 1750 (1995).

    Article  CAS  Google Scholar 

  39. S. Senel, B. Isik-Uruksoy, H. Çiçek and A. Tuncel, J. Appl. Polym. Sci., 64, 1775 (1997).

    Article  CAS  Google Scholar 

  40. E. V. Anufrieva, R. A. Gromova, Y. E. Kirsh, N. A. Yanul, M. G. Krakovyak, V. B. Lushchik, V. D. Pautov and T. V. Sheveleva, Eur. Polym. Sci., 37, 323 (2001).

    Article  CAS  Google Scholar 

  41. F. Eeckman, A. J. Moes and K. Amighi, Eur. Polym. J., 40, 873 (2004).

    Article  CAS  Google Scholar 

  42. N. Pekel, N. Şahiner, O. Güven and Z.M.O. Rzaev, Eur. Polym. J., 37, 2443 (2001).

    Article  CAS  Google Scholar 

  43. J. Brandrup and E. H. Immergut, Polymer Handbook, 3rd ed., John Wiley & Sons, New York, 1989, p. II-274.

    Google Scholar 

  44. B. V. Robinson, F. M. Sallivan, J. F. Borzelleca and S. L. Schwartz, Poly(vinyl pyrrolidone), Levis Publishers, Michigan, 1990, p. 209.

    Google Scholar 

  45. M. Fineman and S. D. Ross, J. Polym. Sci., 5, 259 (1950).

    Article  CAS  Google Scholar 

  46. T. Kelen and F. Tüdös, J. Macromol. Sci., Chem. A, 9, 1 (1975).

    Article  Google Scholar 

  47. M. Dube, R. Amin Sanayei, A. Penlidis, K. F. O'Driscoll and P. M. Reilly, J. Polym. Sci., A-2 Polym. Chem., 29, 703 (1991).

    Article  CAS  Google Scholar 

  48. P. Molineux, Water Soluble Synthetic Polymers; Properties and Behavior, CRC Press, Boca Raton, FL, 1983, Vol. 1, p. 146.

    Google Scholar 

  49. Ü. Salamova, A. A. Masimov and Z. M. O. Rzaev, Polymer, 37, 2415 (1996).

    Article  CAS  Google Scholar 

  50. G. Odian, Principles of Polymerization, 3rd ed., John Wiley & Sons Inc., New York, 1991, p. 480.

    Google Scholar 

  51. A. Durand and D. Hourdet. Polymer, 41, 545 (2000).

    Article  CAS  Google Scholar 

  52. O. Chiantore, M. Guaita and L. Trossarelli, Makromol.Chem., 180, 2019 (1979).

    Article  CAS  Google Scholar 

  53. G. B. Levy and H. P. Frank, J. Polym. Sci., 17, 247 (1953).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemical Engineering and Division of Bioengineering, Faculty of Engineering, Hacettepe University, Beytepe, 06532, Ankara, Turkey

    Sevil Dincer, Zakir M. O. Rzaev & Erhan Piskin

Authors
  1. Sevil Dincer
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Zakir M. O. Rzaev
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Erhan Piskin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Zakir M. O. Rzaev.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dincer, S., Rzaev, Z.M.O. & Piskin, E. Synthesis and Characterization of Stimuli-Responsive Poly(N-isopropylacrylamide-co-N-vinyl-2-pyrrolidone). J Polym Res 13, 121–131 (2006). https://doi.org/10.1007/s10965-005-9014-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10965-005-9014-x

Key words

Search

Navigation