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A System of Interacting Neurons with Short Term Synaptic Facilitation

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Abstract

In this paper we present a simple microscopic stochastic model describing short term plasticity within a large homogeneous network of interacting neurons. Each neuron is represented by its membrane potential and by the residual calcium concentration within the cell at a given time. Neurons spike at a rate depending on their membrane potential. When spiking, the residual calcium concentration of the spiking neuron increases by one unit. Moreover, an additional amount of potential is given to all other neurons in the system. This amount depends linearly on the current residual calcium concentration within the cell of the spiking neuron. In between successive spikes, the potentials and the residual calcium concentrations of each neuron decrease at a constant rate. We show that in this framework, short time memory can be described as the tendency of the system to keep track of an initial stimulus by staying within a certain region of the space of configurations during a short but macroscopic amount of time before finally being kicked out of this region and relaxing to equilibrium. The main technical tool is a rigorous justification of the passage to a large population limit system and a thorough study of the limit equation.

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Acknowledgements

The authors thank two anonymous referees for useful remarks and careful reading. AG and EL thank the Gran Sasso Science Institute (GSSI) for hospitality and support. This research is part of USP project Mathematics, computation, language and the brain and of FAPESP project Research, Innovation and Dissemination Center for Neuromathematics (Grant 2013/07699-0). AG is partially supported by CNPq fellowship (Grant 311 719/2016-3).

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Authors and Affiliations

  1. Universidade de São Paulo, São Paulo, Brazil

    A. Galves

  2. Université de Paris 1 Panthéon Sorbonne, Paris, France

    E. Löcherbach

  3. Université Paris Descartes, Paris, France

    C. Pouzat

  4. Gran Sasso Science Institute, L’Aquila, Italy

    E. Presutti

Authors
  1. A. Galves
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  2. E. Löcherbach
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  3. C. Pouzat
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  4. E. Presutti
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Correspondence to A. Galves.

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Communicated by Eric A. Carlen.

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Galves, A., Löcherbach, E., Pouzat, C. et al. A System of Interacting Neurons with Short Term Synaptic Facilitation. J Stat Phys 178, 869–892 (2020). https://doi.org/10.1007/s10955-019-02467-1

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  • DOI: https://doi.org/10.1007/s10955-019-02467-1

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