Abstract
We introduce a continuous time stochastic process on strings made of two types of particle, whose dynamics mimics that of microtubules in a living cell. The long term behaviour of the system is described in terms of the velocity v of the string end. We show that v is an analytic function of its parameters and study its monotonicity properties. We give a complete characterisation of the phase diagram of the model and derive several criteria of the growth (\(v>0\)) and the shrinking (\(v<0\)) regimes of the dynamics.
Similar content being viewed by others
References
Antal, T., Krapivsky, P.L., Redner, S., Mailman, M., Chakraborty, B.: Dynamics of an idealized model of microtubule growth and catastrophe. Phys. Rev. E 76, 041907 (2007)
Dembo, A., Zeitouni, O.: Large Deviations Techniques and Applications, Volume 38 of Applications of Mathematics (New York). Springer, New York, second edition (1998)
den Hollander, F.: Large Deviations. Fields Institute Monographs. American Mathematical Society, Providence, RI (2000)
Howard, J., Hyman, A.A.: Dynamics and mechanics of the microtubule plus end. Nature 422, 753–758 (2003)
Hryniv, O.: Regular phase in a model of microtubule growth. Markov Process. Relat. Fields 18(2), 177–200 (2012)
Hryniv, O., Letcher, A., Sheard, D.: Re-entrant transition in a model of microtubule growth. [in preparation]
Hryniv, O., Menshikov, M.: Long-time behaviour in a model of microtubule growth. Adv. Appl. Probab. 42(1), 268–291 (2010)
Mitchison, T., Kirschner, M.: Dynamic instability of microtubule growth. Nature 312, 237–242 (1984)
Norris, J.R.: Markov Chains, Volume 2 of Cambridge Series in Statistical and Probabilistic Mathematics. Cambridge University Press, Cambridge (1998). Reprint of 1997 original
Piette, B.M.A.G., Liu, J., Peeters, K., Smertenko, A., Hawkins, T., Deeks, M., Quinlan, R., Zakrzewski, W.J., Hussey, P.J.: A thermodynamic model of microtubule assembly and disassembly. PLos ONE 4, e6378 (2009)
Walker, R.A., O’Brien, E.T., Pryer, N.K., Soboeiro, M.E., Voter, W.A., Erickson, H.P., Salmon, E.D.: Dynamic instability of individual microtubules analyzed by video light microscopy: rate constants and transition frequencies. J. Cell Biol. 107, 1437–1448 (1988)
Weisenberg, R.C.: Microtubule formation in vitro in solutions containing low calcium concentrations. Science 177(4054), 1104–1105 (1972)
Weisenberg, R.C., Deery, W.J., Dickinson, P.J.: Tubulin-nucleotide interactions during the polymerization and depolymerization of microtubules. Biochemistry 15(19), 4248–4254 (1976)
Acknowledgements
This work was started when the second author (AME) visited the UK within the IAESTE exchange programme. He thanks Durham University for hospitality.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Hryniv, O., Martínez Esteban, A. Stochastic Model of Microtubule Dynamics. J Stat Phys 169, 203–222 (2017). https://doi.org/10.1007/s10955-017-1855-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10955-017-1855-2
Keywords
- Microtubules
- Phase transition
- Birth-and-death process
- Renewal decomposition
- Stochastic domination
- Coupling