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Simple Model Study of Phase Transition Properties of Isolated and Aggregated Protein

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Abstract

We investigate the phase transition properties of isolated and aggregated protein by exhaustive numerical study in the confined conformation space with maximally compact lattice model. The study within the confined conformation space shows some general folding properties. Various sequences show different folding properties: two-state folding, three-state folding and prion-like folding behavior. We find that the aggregated protein holds a more evident transition than isolated one and the transition temperature is generally lower than that in isolated case.

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Authors and Affiliations

  1. Department of Physics, Wenzhou University, Wenzhou, 325035, P.R. China

    Yong-Yun Ji, Wei-Qi Yi & Lin-Xi Zhang

  2. Department of Physics, ZheJiang University, Hangzhou, 310027, P.R. China

    Lin-Xi Zhang

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  1. Yong-Yun Ji
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  2. Wei-Qi Yi
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Correspondence to Yong-Yun Ji.

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Ji, YY., Yi, WQ. & Zhang, LX. Simple Model Study of Phase Transition Properties of Isolated and Aggregated Protein. J Stat Phys 142, 975–983 (2011). https://doi.org/10.1007/s10955-011-0148-4

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  • DOI: https://doi.org/10.1007/s10955-011-0148-4

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