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Solubility Studies of Amlodipine Besylate in Propylene Glycol + Ethanol Mixtures at Different Temperatures

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Abstract

In this research, the solubility of amlodipine besylate was studied in the propylene glycol + ethanol mixtures at different temperatures (293.2–313.2 K). The study showed that the solubility increases with an increase in propylene glycol concentration, reaching its highest point at w1 = 0.8. Additionally, the solubility values have a positive correlation with temperature, which is typical for the solid solutes. The experimental solubility data were correlated with some well known cosolvency models and the accuracy of these models was investigated with the mean relative deviations (MRDs%) of the back-calculated data. MRDs were 1.2% for the van’t Hoff model, 4.3 and 4.6% for the Jouyban–Acree and Jouyban–Acree–van’t Hoff equations, 1.4% for the MRS model and 2.1% for the modified Wilson model. The apparent thermodynamic parameters (standard state Gibbs energy, enthalpy, and entropy) of dissolution of ADB in the non-aqueous saturated mixtures were also calculated with the van’t Hoff and Gibbs equations at Thm = 303.0 K.

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Data Availability

No datasets were generated or analysed during the current study.

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Acknowledgements

This work was supported by the Student Research Committee, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran under grant number 67776.

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Authors and Affiliations

  1. Student Research Committee, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran

    Homa Rezaei

  2. Pharmaceutical Analysis Research Center, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran

    Homa Rezaei, Nastaran Hashemzadeh, Elaheh Rahimpour & Abolghasem Jouyban

  3. Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, 5165665811, Iran

    Elaheh Rahimpour

  4. Grupo de Investigaciones Farmacéutico-Fisicoquímicas, Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia-Sede Bogotá, Cra. 30 No. 45-03, Bogotá, D.C, Colombia

    Fleming Martinez

  5. Faculty of Pharmacy, Near East University, Mersin 10, PO BOX: 99138, Nicosia, North Cyprus, Turkey

    Abolghasem Jouyban

Authors
  1. Homa Rezaei
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  2. Nastaran Hashemzadeh
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  3. Elaheh Rahimpour
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  4. Fleming Martinez
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  5. Abolghasem Jouyban
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Contributions

Homa Rezaei; Investigation, Nastaran Hashemzadeh; Data curation, drafting the first version , Elaheh Rahimpour: Supervision, Writing—review & editing. Fleming Martinez, Data curation, Abolghasem Jouyban; Supervision, Writing—review & editing. All authors read and approved the final manuscript.

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Correspondence to Elaheh Rahimpour.

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Rezaei, H., Hashemzadeh, N., Rahimpour, E. et al. Solubility Studies of Amlodipine Besylate in Propylene Glycol + Ethanol Mixtures at Different Temperatures. J Solution Chem (2024). https://doi.org/10.1007/s10953-024-01373-9

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  • DOI: https://doi.org/10.1007/s10953-024-01373-9

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