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Simulation of Clozapine Solubility in Mono- and Mixed Solvents at Different Temperatures

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Abstract

The current study validated some trained models for predicting clozapine solubility data in mono- and binary-solvent mixtures. The prediction models were built by combining the van't Hoff and Jouyban–Acree models with various physicochemical characteristics such as Abraham solvation parameters and Catalan and Hansen solubility parameters. The overall mean relative deviation and cross-validation analyses were used to assess the models' accuracy and applicability. Validated models can be used to estimate the clozapine solubility in mono-solvents or solvent mixtures at various temperatures.

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Acknowledgements

We are grateful to Tabriz University of Medical Sciences for the financial support of this research (Grant No: 67898).

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Authors and Affiliations

  1. Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran

    Elaheh Rahimpour & Abolghasem Jouyban

  2. Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Elaheh Rahimpour

  3. Guangling College, Yangzhou University, Yangzhou, 225000, Jiangsu, People’s Republic of China

    Renjie Xu

  4. College of Chemistry & Chemical Engineering, YangZhou University, Yangzhou, 225002, Jiangsu, People’s Republic of China

    Hongkun Zhao

  5. Department of Chemistry, University of North Texas, Denton, TX, 76203-5070, USA

    William E. Acree Jr.

  6. Faculty of Pharmacy, Near East University, Mersin 10, PO BOX: 99138, Nicosia, North Cyprus, Turkey

    Abolghasem Jouyban

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  1. Elaheh Rahimpour
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  2. Renjie Xu
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  3. Hongkun Zhao
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  5. Abolghasem Jouyban
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Correspondence to Hongkun Zhao.

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Rahimpour, E., Xu, R., Zhao, H. et al. Simulation of Clozapine Solubility in Mono- and Mixed Solvents at Different Temperatures. J Solution Chem 51, 1540–1570 (2022). https://doi.org/10.1007/s10953-022-01208-5

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