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Solubility, Dissolution Thermodynamics and Preferential Solvation of Meloxicam in (Methanol + Water) Mixtures

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Abstract

Solubility of meloxicam in {methanol + water} mixtures from 293.15 to 313.15 K has been determined and correlated by means of the Jouyban–Acree model. By using the van’t Hoff and Gibbs equations the respective apparent thermodynamic quantities for the dissolution and mixing processes, namely Gibbs energy, enthalpy, and entropy, were calculated. A non-linear enthalpy–entropy relationship was observed in the plot of enthalpy vs. Gibbs energy exhibiting negative but variable slopes in the composition region 0.00 < x1 < 0.60 and variable negative and positive slopes in the other mixtures. Based on the inverse Kirkwood–Buff integrals it follows that meloxicam is preferentially solvated by water molecules in water-rich mixtures but preferentially solvated by methanol molecules in mixtures 0.31 < x1 < 1.00.

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Acknowledgements

We thank the Departments of Pharmacy and Physics of the Universidad Nacional de Colombia for facilitating the equipment and laboratories used. Financial support of Colciencias is also highly appreciated.

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Authors and Affiliations

  1. Grupo de Investigaciones Farmacéutico-Fisicoquímicas, Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia, Sede Bogotá, Cra. 30 No. 45-03, Bogotá, DC, Colombia

    Darío A. Tinjacá & Fleming Martínez

  2. Grupo de Física Aplicada, Departamento de Física, Facultad de Ciencias, Universidad Nacional de Colombia, Sede Bogotá, Cra. 30 No. 45-03, Bogotá, DC, Colombia

    Ovidio A. Almanza

  3. Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, 51664, Tabriz, Iran

    Abolghasem Jouyban

  4. School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Abolghasem Jouyban

  5. Department of Chemistry, University of North Texas, Denton, TX, 76203-5070, USA

    William E. Acree Jr.

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  1. Darío A. Tinjacá
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  2. Fleming Martínez
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Tinjacá, D.A., Martínez, F., Almanza, O.A. et al. Solubility, Dissolution Thermodynamics and Preferential Solvation of Meloxicam in (Methanol + Water) Mixtures. J Solution Chem 50, 667–689 (2021). https://doi.org/10.1007/s10953-021-01084-5

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