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Volumetric, UV–Vis and FT IR Studies of Isoniazid in Diethylsulfoxide Solutions

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Abstract

UV–Vis, FT IR spectroscopy and densitometry were used to study solutions of isoniazid (INH) in diethylsulfoxide (DESO). The apparent molar volumes of INH were calculated from density data at 298.15, 310.15 and 328.15 K. The limiting apparent molar volume was found by extrapolation to infinite dilution using the Redlich–Mayer equation. From detailed analysis of FT IR spectra of INH in DESO, complex formation through hydrogen bonds between INH and sulfoxide molecules was revealed. Also UV–Vis data confirm the formation of hydrogen bonds between the NH2 group of INH and the SO group of the sulfoxide. The obtained data were compared with those of dimethylsulfoxide solutions.

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Acknowledgements

The research was supported by the Science Committee of the Republic of Armenia.

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  1. Department of Chemistry, Yerevan State University, A. Manoogian St. 1, 0025, Yerevan, Armenia

    Shiraz A. Markarian, Zakar K. Papanyan & Gohar A. Shahinyan

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  1. Shiraz A. Markarian
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  2. Zakar K. Papanyan
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Correspondence to Shiraz A. Markarian.

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Markarian, S.A., Papanyan, Z.K. & Shahinyan, G.A. Volumetric, UV–Vis and FT IR Studies of Isoniazid in Diethylsulfoxide Solutions. J Solution Chem 49, 1094–1106 (2020). https://doi.org/10.1007/s10953-020-01015-w

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