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Thermodynamic Study on the Interaction of Nicotinic Acid with H+, Na+, Ca2+ and Mg2+ at Different Temperatures and Ionic Strengths

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Abstract

Protonation of nicotinic acid has been investigated by means of potentiometric titrations at different temperatures 283.15 ≤ T (K) ≤ 383.15 and ionic strengths of NaCl(aq), 0.12 ≤ I (mol·kg−1) ≤ 4.84 and mixed NaCl with MgCl2 or CaCl2. Stability constants of the CaL+ and MgL+ species were obtained by means of the ΔpK method. Different models (e.g. Debye–Hückel type equation, Specific Ion Interaction Theory, Pitzer and van’t Hoff) were applied to account for the ionic strength and temperature dependences, in order to obtain data in a standard state and parameters to calculate stability constants in any point of our experimental domain. Speciation studies were performed simulating the conditions of natural fluids. Literature data were investigated for comparison with the experimental results here obtained.

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Abbreviations

p :

Pressure

I :

Ionic strength

T :

Temperature in Kelvin degrees

u :

Uncertainty

L− :

Deprotonated ligand

log10 γ:

Logarithm of the activity coefficient

C i :

Ionic strength dependence parameter for the ith protonation step in the EDH equation

k m :

Setschenow coefficient, salt coefficient

εik :

Specific interaction coefficient of the species i with the species k

A :

Constant of the Debye–Hückel equation, dependent on temperature

θ :

Term of the Pitzer equation accounting for binary interactions of ions of same sign but different charge interactions

ψ :

Term of the Pitzer equation accounting for the triple interactions

(ΔH 0)0 :

Standard protonation enthalpy at infinite dilution

τ :

Reference temperature, 298.15 K in our case

log10K M :

Logarithm of the stability constant of the ML species, superscript “0” indicates infinite dilution

c 0 and c 1 :

Ionic strength dependence parameters of the weak interaction model

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Acknowledgements

This research was supported by MIUR (Grant PRIN 2015 - 2015MP34H3) for partial funding.

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Authors and Affiliations

  1. Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran

    Kavosh Majlesi

  2. Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Università degli Studi di Messina, Viale Ferdinando Stagno d’Alcontres, 31, 98166, Messina (Vill. S. Agata), Italy

    Clemente Bretti, Concetta De Stefano, Gabriele Lando & Silvio Sammartano

  3. Private Laboratory, Tehran, Iran

    Kimia Majlesi

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  1. Kavosh Majlesi
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  2. Clemente Bretti
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Majlesi, K., Bretti, C., De Stefano, C. et al. Thermodynamic Study on the Interaction of Nicotinic Acid with H+, Na+, Ca2+ and Mg2+ at Different Temperatures and Ionic Strengths. J Solution Chem 48, 1671–1684 (2019). https://doi.org/10.1007/s10953-019-00915-w

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