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Experimental and Thermodynamic Modeling of Quaternary Aqueous Two-Phase System of Poly Ethylene Glycol, Sodium Tartrate, Water and Penicillin G

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Abstract

In present study, the liquid–liquid equilibrium of the quaternary system of polyethylene glycol (PEG) (with molar masses of 1000, 2000, 6000, and 8000 g·mol−1), sodium tartrate salt, Penicillin G and water at 298 K were investigated. The partitioning of Penicillin G between two aqueous phases was also reported. The extended non random two liquid (NRTL) and extended Universal Quasi Chemical (UNIQUAC) models were used to correlate the experimental equilibrium data. The parameters of these activity coefficient models were optimized for the investigated systems. The results show that the polymer molar mass has a dominant effect on the partition coefficient of Penicillin G. Also, results of both thermodynamic models were very satisfactory and satisfactory predicted the equilibrium concentrations of the components in ATPS. Comparison of the absolute average deviation of the two models shows that the extended UNIQUAC model was superior to the extended NRTL model for correlation and interpolation of phase equilibrium data.

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Abbreviations

n D :

Refractive index

w s :

Mass fraction of the sodium tartrate

w p :

Mass fraction of PEG

Z a :

Charge number of the anion

Z b :

Charge number of the cation

A, b :

Debye–Hückel parameters

I :

Ionic strength of solution

m :

Molality of ion

d :

Density

D :

Dielectric constant

ϕ :

Salt-free volume fraction

v :

Molar volume

n :

Mole number

M w :

Molecular weight

Z :

Coordination number

x :

Mole fraction

ʋ s :

Stoichiometric coefficients of salt

\(\tau_{ij}\) :

Boltzmann factor

T :

Temperature

a ij :

Adjustable binary interaction parameter of i–j pair

\(\gamma\) :

Activity coefficient

K :

Partition coefficient

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Acknowledgement

The authors acknowledge the funding support of Babol Noshirvani University of Technology for this study, through Grant Program No. BNUT/390058/96.

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Authors and Affiliations

  1. Faculty of Chemical Engineering, Babol Noshirvani University of Technology, P.O. Box, 484, Babol, Iran

    Sanaz Edrisi, Hamid Bakhshi & Mostafa Rahimnejad

  2. Department of Chemical Engineering, Biofuel and Renewable Energy Research Center, Babol Noshirvani University of Technology, Babol, Iran

    Mostafa Rahimnejad

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  1. Sanaz Edrisi
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  2. Hamid Bakhshi
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Correspondence to Hamid Bakhshi.

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Edrisi, S., Bakhshi, H. & Rahimnejad, M. Experimental and Thermodynamic Modeling of Quaternary Aqueous Two-Phase System of Poly Ethylene Glycol, Sodium Tartrate, Water and Penicillin G. J Solution Chem 48, 1206–1221 (2019). https://doi.org/10.1007/s10953-019-00906-x

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