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Comparison of the Models for Correlation of Drug Solubility in Ethanol + Water Binary Mixtures

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Abstract

The ability of a number of common models for correlating the collected solubility data of drugs in ethanol + water mixtures (the number of data sets is 43) was tested. The selected models are classified within three groups, (1) λ–h, van’t Hoff and Apelblat models with temperature dependency, and modified Wilson with solvent composition dependency, (2) Jouyban–Acree, Jouyban–Acree–van’t Hoff and Jouyban–Acree–Apelblat (linear models) and NRTL, Wilson and UNIQUAC (nonlinear models) with both temperature and solvent composition dependencies, (3) UNIFAC, Yalkowsky, log–linear model of Yalkowsky, Jouyban–Acree–Abraham and Jouyban–Acree–Hansen predictive models. Of the models in group 1, the Apelblat model has the lowest overall %ARD and Jouyban–Acree–van’t Hoff and Jouyban–Acree–Apelblat models in group 2 performed best in correlations. Moreover, predictions using Jouyban–Acree–Abraham and Jouyban–Acree–Hansen models in group 3 have the lowest %ARDs in this group.

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Authors and Affiliations

  1. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Seyyedeh Narjes Mirheydari & Ali Shayanfar

  2. Research Center for Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran

    Mohammad Barzegar-Jalali

  3. Department of Chemistry, University of North Texas, Denton, TX, 76203-5070, USA

    William E. Acree Jr.

  4. Department of Physical Chemistry, Faculty of Chemistry, University of Tabriz, Tabriz, Iran

    Hemayat Shekaari

  5. Pharmaceutical Analysis Research Center, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran

    Abolghasem Jouyban

  6. Kimia Idea Pardaz Azarbayjan (KIPA) Science Based Company, Tabriz University of Medical Sciences, Tabriz, Iran

    Abolghasem Jouyban

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  1. Seyyedeh Narjes Mirheydari
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Mirheydari, S.N., Barzegar-Jalali, M., Acree, W.E. et al. Comparison of the Models for Correlation of Drug Solubility in Ethanol + Water Binary Mixtures. J Solution Chem 48, 1079–1104 (2019). https://doi.org/10.1007/s10953-019-00897-9

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