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Preferential Solvation of Vitamin C in Binary Solvent Mixtures Formed by Methanol, Ethanol, n-Propanol, Isopropanol and Water

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Abstract

The present work is an investigation of the preferential solvation of vitamin C in five solvent mixtures: ethanol (1) + methanol (2), isopropanol (1) + methanol (2), ethanol (1) + water (2), n-propanol (1) + water (2) and isopropanol (1) + water (2) from the reported solubility data by employing the method of inverse Kirkwood–Buff integrals. In the ethanol (1) + water (2) mixtures with compositions 0.25 < x1 < 1.00, and isopropanol (1) + water (2) and n-propanol (1) + water (2) mixtures with compositions 0.20 < x1 < 1.00, the local mole fractions of ethanol, isopropanol or n-propanol are smaller than those of the bulk solutions. Consequently, the values of preferential solvation parameter (δx1,3) are negative, which shows that vitamin C is preferentially solvated by water. Perhaps the structuring of water molecules near the vitamin C molecule contributes to lowering of the δx1,3 from the neat solvent water to negative values in the three solvent mixtures. Vitamin C acts as a Lewis base that interacts with the acidic hydrogen atoms of water. Nevertheless, in the ethanol (1) + methanol (2) and isopropanol (1) + methanol (2) mixtures, vitamin C is preferentially solvated neither by methanol nor by ethanol nor isopropanol.

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Authors and Affiliations

  1. Laboratory and Equipment Management Office, Taizhou University, Taizhou, 225300, Jiangsu, People’s Republic of China

    Yuxiu Li

  2. Department of Chemistry, Jouybar Branch, Islamic Azad University, Jouybar, Iran

    Ali Farajtabar

  3. College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou, 225002, Jiangsu, People’s Republic of China

    Zhao Hongkun

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  1. Yuxiu Li
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  2. Ali Farajtabar
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  3. Zhao Hongkun
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Correspondence to Zhao Hongkun.

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Li, Y., Farajtabar, A. & Hongkun, Z. Preferential Solvation of Vitamin C in Binary Solvent Mixtures Formed by Methanol, Ethanol, n-Propanol, Isopropanol and Water. J Solution Chem 48, 200–211 (2019). https://doi.org/10.1007/s10953-019-00857-3

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