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Solubility of Ketoconazole in Binary and Ternary Solvents of Polyethylene Glycols 200, 400 or 600 with Ethanol and Water at 298.2 K. Data Report and Analysis

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Abstract

The solubilities of ketoconazole in binary and ternary mixtures of water, ethanol and polyethylene glycols 200, 400 or 600 (185 data points) were determined at 298.2 K. Williams–Amidon and Jouyban–Acree cosolvency models were used to model the data, with overall mean relative deviations (OMRDs) for the solubility data in binary and ternary solvents of 17.5 and 23.5%, respectively. For predicting the solubility data of ketoconazole the trained versions of the models were used and the OMRD values were 47.7 and 33.0%, respectively.

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Acknowledgements

This paper is resulted from a Pharm.D thesis with the Proposal Number of (A-11-387-8). The authors are grateful for financial support from Zanjan University of Medical Sciences, Iran.

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  1. Faculty of Pharmacy, Zanjan University of Medical Sciences, Zanjan, 45139, Iran

    Shahla Soltanpour & Vahideh Nazemi

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  1. Shahla Soltanpour
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  2. Vahideh Nazemi
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Correspondence to Shahla Soltanpour.

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Soltanpour, S., Nazemi, V. Solubility of Ketoconazole in Binary and Ternary Solvents of Polyethylene Glycols 200, 400 or 600 with Ethanol and Water at 298.2 K. Data Report and Analysis. J Solution Chem 47, 65–79 (2018). https://doi.org/10.1007/s10953-017-0708-6

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  • DOI: https://doi.org/10.1007/s10953-017-0708-6

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