Abstract
A chemical investigation of the interaction mechanisms of nicotine with the metal(II) ions Pb\( ^{2+} \), Fe\( ^{2+} \), and Cu\( ^{2+} \) is reported. The complex formation between nicotine and metal(II) has been investigated at 25.00 \( \pm \) 0.02 \(^{\circ }\)C, in constant ionic medium (as sodium perchlorate, or sodium chloride), by UV/Vis spectrophotometric and potentiometric methods. The experimental method consists of coulometric or volumetric titrations. The protolysis constants of nicotine have been determined under the same experimental conditions. The pH investigated spans between 3 and 10. By using the specific ion interaction theory the conditional constants of nicotine have been extrapolated at zero ionic strength. The results of the graphical and numerical methods adopted indicate, for all the systems investigated, the formation of a predominating Me(II)/nicotine mononuclear complexes.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Jain, R., Mukherjee, K.: Biological basis of nicotine addiction. Indian J. Pharm. 35, 281–289 (2003)
Guan, Z.Z., Yu, W.F., Nordberg, A.: Dual effects of nicotine on oxidative stress and neuroprotection in PC12 cells. Neurochem. Int. 43, 243–249 (2003)
Soto-Otero, R., Mendez-Alvarez, E., Hermida-Ameijeiras, A., Lopez-Real, A.M., Labandeira-Garcia, J.L.: Effects of (2)-nicotine and (2)-cotinine on 6-hydroxydopamine-induced oxidative stress and neurotoxicity: relevance for Parkinson’s disease. Biochem. Pharmacol. 64, 125–135 (2002)
Yildiz, D.: Nicotine, its metabolism and an overview of its biological effects. Toxicon 43, 619–632 (2004)
Aoshiba, K., Nagai, A., Yasui, S., Konno, K.: Nicotine prolongs neutrophil survival by suppressing apoptosis. J. Lab. Clin. Med. 127, 186–194 (1996)
Konno, S., Oronsky, B.T., Semproni, A.R., Wu, J.M.: The effect of nicotine on cell proliferation and synthesis of secreted proteins in BALB/C 3T3 cells. Biochem. Int. 25, 7–17 (1991)
Bridge, M.H., Williams, E., Lyons, M.E.G., Tipton, K.F., Linert, W.: Electrochemical investigation into the redox activity of Fe(II)/Fe(III) in the presence of nicotine and possible relations to neurodegenerative diseases. Biochim. Biophys. Acta 1690, 77–84 (2004)
Hernán, M.A., Takkouche, B., Caamaño-Isorna, F., Gestal-Otero, J.J.: A meta-analysis of coffee drinking, cigarette smoking, and the risk of Parkinson’s disease. Ann. Neurol. 52, 276–284 (2002)
Morel, D.W., Hasler, J.R., Clistom, G.M.: Low density lipoprotein cytotoxicity induced by free radicals peroxidation of lipid. J. Lipid Res. 24, 1970–1976 (1963)
Pre, J., Le Floch, A., Vassy, R., Le Noble, C.: Increased plasma level of fluorescent lipid peroxidation products in cigarette smokers. Med. Sci. Res. 17, 1029–1030 (1989)
Munir, C., Zaidi, M.I., Yousaf, S.M.: Zinc, cadmium and mercury as extractants of nicotine from tobacco leaves. Main Group Met. Chem. 17, 673–677 (1994)
Gillard, R.D., de Jesus, J.D.P., Mohammad, A.Y.A.: Coordination compounds and microorganisms, Part 12. Rhodium compounds of S-nicotine and their bacterial activity. Transit. Met. Chem. 14, 258–260 (1989)
Jasiewicz, B., Hoffmann, M., Gasowska, A., Jastrzab, R., Malczewska-Jaska, K.A.: Spectroscopic, potentiometric and quantum-mechanical studies of S-(\({-}\))-nicotine complexes with Cu(II). Acta Chim. Slov. 61, 137–144 (2014)
Zhou, M., Suszkiw, J.B.: Nicotine attenuates spatial learning deficits induced in the rat by perinatal lead exposure. Brain Res. 999, 142–147 (2004)
Biedermann, G.: The hydrolysis of the indium(III) ion, In\(^{3+}\). Ark. Kemi 9, 277–293 (1956)
Brown, A.S.: A type of silver chloride electrode suitable for use in dilute solutions. J. Am. Chem. Soc. 56, 646–647 (1934)
Biedermann, G., Sillén, L.G.: Studies on the hydrolysis of metal ions. IV. Ark. Kemi 40, 425–440 (1953)
Gran, G.: Determination of the equivalence point in potentiometric titrations. Part II. Analyst 77, 661–671 (1952)
Sillén, L.G., Warnqvist, B.: High-speed computers as a supplement to graphical methods. VI. A strategy for two-level Letagrop adjustment of common and group parameters. Features that avoid divergence. Ark. Kemi 31, 315–339 (1969)
Rossotti, F.J.C., Rossotti, H.S.: The Determination of Stability Constants and Other Equilibrium Constants in Solution. McGraw-Hill, New York (1961)
Gans, P., Sabatini, A., Vacca, A.: Investigation of equilibria in solution. Determination of equilibrium constants with the HYPERQUAD suite programs. Talanta 43, 1739–1753 (1996)
Biedermann, G.: The hydrolysis of metal ions. XIV. The hydrolysis of the indium(III) ion. Ark. Kemi 9, 227 (1956)
Olin, A.: Studies on the hydrolysis of metal ions. 25. The hydrolysis of lead(II) in perchlorate medium. Acta Chem. Scand. 14, 126–150 (1960)
Biedermann, G., Ferri, D.: On the polynuclear hydrolysis of indium ion, In\(^{3+} \). Acta Chem. Scand. A 36, 622 (1982)
Baes, C.F., Mesmer, R.E.: The Hydrolysis of Cations. R. E. Krieger Publishing Company Inc., Krieger Drive Malabar (1976)
Zhang, J., Liu, Q., Chen, Q., Liu, N.Q., Li, F.L., Lu, Z.B., Zhao, B.L.: Nicotine attenuates–amyloid-induced neurotoxicity by regulating metal homeostasis. Acta Chim. Slov. FASEB J. 20, E399–E408 (2006)
Liu, Q., Zhao, B.L.: Nicotine attenuates \( - \) amyloid peptide-induced neurotoxicity, free radical and calcium accumulation in hippocampal neuronal cultures. Br. J. Pharm. 141, 746–754 (2004)
Acknowledgments
The present work is part of a project financed by BAT, British American Tobacco.
Author information
Authors and Affiliations
Corresponding author
Additional information
D. Ferri died in April 2010. This work was conceived and initiated by Prof. D. Ferri.
Rights and permissions
About this article
Cite this article
Manfredi, C., Vero, S., Vasca, E. et al. On the Interaction Between Nicotine and Metal(II) Ions in Aqueous Solutions. J Solution Chem 45, 971–989 (2016). https://doi.org/10.1007/s10953-016-0483-9
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10953-016-0483-9