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Thermodynamic Studies on Protonation Constant of Acyclovir at Different Ionic Strengths

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Abstract

Stepwise protonation constants of acyclovir were determined at different temperatures (20.0–40.0 °C) and various ionic strengths (0.1–2.0 mol·dm−3 or 0.100–2.086 mol·kg−1 NaCl) using a combination of potentiometric and spectrophotometric methods. The thermodynamic parameters (i.e. enthalpy, ΔH°, and entropy, ΔS°, changes) of the protonations were calculated at different temperatures using the van’t Hoff and virial equations. The dependence of protonation constant on ionic strength was modeled by a Debye–Hückel type equation and is discussed. Finally, the protonation constants of acyclovir and the enthalpy and entropy changes of the protonations were determined at zero ionic strength.

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Acknowledgments

Financial support by the Research Council of Roudehen Branch, Islamic Azad University, is gratefully acknowledged.

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Correspondence to Farahnaz Soleimani.

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Soleimani, F., Karimi, R. & Gharib, F. Thermodynamic Studies on Protonation Constant of Acyclovir at Different Ionic Strengths. J Solution Chem 45, 920–931 (2016). https://doi.org/10.1007/s10953-016-0478-6

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  • DOI: https://doi.org/10.1007/s10953-016-0478-6

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