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Di- and Tri-valent Metal Ions Interactions with Four Biodegradable Hydroxamate and Cataecholate Siderophores: New Insights into Their Complexation Equilibria

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Abstract

The interaction of a number of divalent and trivalent metal ions [iron(III), chromium(III) copper(II), cobalt(II) and nickel(II)] with four isolated and purified microbial catecholate and hydroxamate siderophores was studied using the pH-potentiometric technique to investigate the complexation behavior of these systems as these systems could mimic many biological interactions of the siderophore chelating agent. The protonation constants of these new siderophore analogues as well their binary complex species stability constants were determined using the Hyperquad 2008 estimation model program. From the determined stability constants of the metal complex species, the concentration distribution of the various metal ion complex species involving isolated siderophore analogues in solutions was estimated using the HySS 2009 modeling program. The complex species distribution diagrams were plotted and discussed. Additionally, the Gibbs energies and the molecular structures of the formed complex species were evaluated and predicted using Gaussian 09 software for molecular modeling and density functional theory calculations.

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Funding

This work was financially supported by King Abdulaziz City for Science and Technology (KACST), Saudi Arabia, through the project number MS_34_41.

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Authors and Affiliations

  1. Chemistry Department, Faculty of Science, King Khalid University, Abha, 9004, Kingdom of Saudi Arabia

    Ahmed E. Fazary & Ayed S. Al-Shihri

  2. Biology Department, Faculty of Science, King Khalid University, Abha, 9004, Kingdom of Saudi Arabia

    Kamel A. Saleh, Mohammad Y. Alfaifi & Mohammed A. Alshehri

  3. Egyptian Organization for Biological Products and Vaccines [VACSERA Holding Company], 51 Wezaret El-Zeraa St., Agouza, Giza, Egypt

    Ahmed E. Fazary & Serag Eldin I. Elbehairi

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  1. Ahmed E. Fazary
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  2. Ayed S. Al-Shihri
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Correspondence to Ahmed E. Fazary.

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Fazary, A.E., Al-Shihri, A.S., Saleh, K.A. et al. Di- and Tri-valent Metal Ions Interactions with Four Biodegradable Hydroxamate and Cataecholate Siderophores: New Insights into Their Complexation Equilibria. J Solution Chem 45, 732–749 (2016). https://doi.org/10.1007/s10953-016-0475-9

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