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Effect of 1-Butyl-3-methylimidazolium Ibuprofenate as an Active Pharmaceutical Ingredient Ionic Liquid (API-IL) on the Thermodynamic Properties of Glycine and l-Alanine in Aqueous Solutions at Different Temperatures

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Abstract

Recently, ionic liquids have been combined with active pharmaceutical ingredients (APIs), and a third generation of ILs has emerged (API-ILs). The effect of a novel ionic liquid containing the ibuprofenate anion as an active pharmaceutical ingredient ionic liquid (API-IL) on the thermodynamic properties of two amino acids, glycine and l-alanine, have been studied. The densities, speeds of sound, viscosities and refractive indices of glycine and l-alanine in water and in aqueous solutions of an API-IL, 1-butyl-3-methylimidazolium ibuprofenate ([BMIM][Ibu]), have been determined at temperatures 288.15–318.15 K. The measured data have been used to calculate the standard partial molar volume \( V_{\phi }^{0} \), partial molar volume of transfer \( \Delta_{\text{tr}} V_{\phi }^{0} \), Hepler’s constant \( (\partial^{2} V_{\phi }^{0} /\partial T^{2} )_{p} \), apparent molar isentropic compressibility \( \kappa_{\phi } \), molar refraction R D, viscosity B coefficient (B) and hydration number parameters n H. All of these parameters are discussed in terms of the competitive interactions occurring between amino acids–[BMIM][Ibu] and amino acids–water.

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Acknowledgments

The authors wish to thank the graduate council of the University of Tabriz for financial support.

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  1. Department of Physical Chemistry, University of Tabriz, Tabriz, Iran

    Hemayat Shekaari, Mohammed Taghi Zafarani-Moattar & Seyyedeh Narjes Mirheydari

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  1. Hemayat Shekaari
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Shekaari, H., Zafarani-Moattar, M.T. & Mirheydari, S.N. Effect of 1-Butyl-3-methylimidazolium Ibuprofenate as an Active Pharmaceutical Ingredient Ionic Liquid (API-IL) on the Thermodynamic Properties of Glycine and l-Alanine in Aqueous Solutions at Different Temperatures. J Solution Chem 45, 624–663 (2016). https://doi.org/10.1007/s10953-016-0462-1

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