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Solubility of Ketoconazole in Polyethylene Glycol 200 + Water Mixtures at 298.2–318.2 K

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Abstract

The solubility of ketoconazole in binary mixtures of polyethylene glycol 200 (PEG 200) + water is reported at temperatures ranging from 298.2 to 318.2 K. The Jouyban–Acree model and its combined version including the van’t Hoff equation were used for correlating the reported data; the obtained mean relative deviations are 9.5 and 9.9 %, respectively. Also, two previously trained versions of the Jouyban–Acree model were used for predicting the reported data points in which the prediction errors were 34.6 and 31.0 %.

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Authors and Affiliations

  1. Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, 51664, Tabriz, Iran

    Abolghasem Jouyban

  2. Pharmaceutical Engineering Laboratory, School of Chemical Engineering, College of Engineering, University of Tehran, P.O. Box 11155/4563, Tehran, Iran

    Abolghasem Jouyban

  3. Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Jafar Soleymani

  4. Faculty of Pharmacy, Zanjan University of Medical Sciences, 45139, Zanjan, Iran

    Shahla Soltanpour

Authors
  1. Abolghasem Jouyban
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  2. Jafar Soleymani
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  3. Shahla Soltanpour
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Correspondence to Abolghasem Jouyban.

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Jouyban, A., Soleymani, J. & Soltanpour, S. Solubility of Ketoconazole in Polyethylene Glycol 200 + Water Mixtures at 298.2–318.2 K. J Solution Chem 43, 950–958 (2014). https://doi.org/10.1007/s10953-014-0171-6

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  • DOI: https://doi.org/10.1007/s10953-014-0171-6

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