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Volumetric Properties of the Nucleoside Thymidine in Aqueous Solution at T = 298.15 K and p = (10 to 100) MPa

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Abstract

Sound speeds have been measured for aqueous solutions of the nucleoside thymidine at T = 298.15 K and at the pressures p = (10, 20, 40, 60, 80, and 100) MPa. The partial molar volumes at infinite dilution, \( V_{2}^{\text{o}} \), the partial molar isentropic compressions at infinite dilution, \( K_{S,2}^{\text{o}} \), and the partial molar isothermal compressions at infinite dilution, \( K_{T,2}^{\text{o}} \) \( \{ K_{T,2}^{\text{o}} = - (\partial V_{2}^{\text{o}} /\partial p)_{T} \} \), have been derived from the sound speeds at elevated pressures using methods described in our previous work. The \( V_{2}^{\text{o}} \) and \( K_{T,2}^{\text{o}} \) results were rationalized in terms of the likely interactions between thymidine and the aqueous solvent. The \( V_{2}^{\text{o}} \) results were also compared with those calculated using the revised Helgeson–Kirkham–Flowers (HKF) equation of state.

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Acknowledgments

Two of us (G.R.H., G.B.J.) are grateful for financial assistance from the Marsden Fund (Contract No. 09-MAU-140).

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Authors and Affiliations

  1. Institute of Fundamental Sciences—Chemistry, Massey University, Private Bag 11 222, Palmerston North, New Zealand

    Gavin R. Hedwig & Geoffrey B. Jameson

  2. Department of Chemistry, University of Bergen, 5020, Bergen, Norway

    Harald Høiland

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Correspondence to Gavin R. Hedwig.

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Hedwig, G.R., Jameson, G.B. & Høiland, H. Volumetric Properties of the Nucleoside Thymidine in Aqueous Solution at T = 298.15 K and p = (10 to 100) MPa. J Solution Chem 43, 804–820 (2014). https://doi.org/10.1007/s10953-014-0162-7

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