Abstract
Novel drug-like spiro-derivatives of 1,3-thiazine were synthesized. Thermodynamic aspects of sublimation processes of the studied compounds were determined using temperature dependencies of the vapor pressures. Thermophysical characteristics of the molecular crystals were obtained and compared with the sublimation and structural parameters. Solubilities of spiro-derivatives in buffer and hexane were measured in the temperature interval 298.15–315.15 K by an isothermal saturation method. Temperature dependencies of partition coefficients for the studied substances in the systems buffer/organic phase were obtained. Thermodynamic functions describing the solubility, solvation and distribution processes were calculated. The diagram enabling analysis of the mechanism of transfer process was applied.
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Acknowledgments
This work was supported by the Grant No. 12-03-00019-a and BioSol project No. 2010-1.1-234-069.
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Perlovich, G.L., Blokhina, S.V., Ol’khovich, M.V. et al. Solubility, Solvation and Distribution of Novel Spiro-Derivatives of 1,3-Thiazine in Aqueous and Organic Solutions. J Solution Chem 42, 2057–2069 (2013). https://doi.org/10.1007/s10953-013-0089-4
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DOI: https://doi.org/10.1007/s10953-013-0089-4