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Determination of Dissociation Constants of Some Antifungal Drugs by Two Different Methods at 298 K

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Abstract

The dissociation constants of eight antifungal drugs (fenticonazole, isoconazole, itraconazole, ketoconazole, miconazole, ornidazole, tinidazole, tioconazole) have been determined in water and acetonitrile–water binary mixtures by two different methods. Different organic percentages of acetonitrile have been used. For the LC studies 62.5, 65.0 % and 70.0 (v/v) acetonitrile–water binary mixtures were used while spectroscopic measurements were done in water, 10.0 and 20.0 % (v/v) acetonitrile–water. The influence of acetonitrile on the dissociation constants was investigated.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Arts and Sciences, Uşak University, 64000, Uşak, Turkey

    Senem Şanlı, Nurullah Şanlı & İbrahim Bulduk

  2. Department of Chemistry, Faculty of Arts and Sciences, Hitit University, 19040, Çorum, Turkey

    Fatma Başaran & Bediha Akmeşe

Authors
  1. Senem Şanlı
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  2. Fatma Başaran
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  3. Nurullah Şanlı
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  4. Bediha Akmeşe
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  5. İbrahim Bulduk
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Correspondence to Senem Şanlı.

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Şanlı, S., Başaran, F., Şanlı, N. et al. Determination of Dissociation Constants of Some Antifungal Drugs by Two Different Methods at 298 K. J Solution Chem 42, 1976–1987 (2013). https://doi.org/10.1007/s10953-013-0083-x

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  • DOI: https://doi.org/10.1007/s10953-013-0083-x

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