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Complex Formation Equilibria of Unusual Seven-Coordinate Fe(EDTA) Complexes with DNA Constituents and Related Bio-relevant Ligands

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Abstract

Seven-coordinate Fe(EDTA)–L complexes, where L represents a DNA constituent (uracil, uridine, thymine, thymidine and inosine), methylamine, ammonium chloride or imidazole, were investigated to resolve the solution chemistry of this system. The results show formation of 1:1 complexes with DNA constituents and the other ligands, supporting the hepta-coordination mode of Fe(III) ion. Stability constants of the complexes were measured by potentiometric titration at 25 °C and ionic strength 0.1 mol⋅L−1 NaNO3. The hydrolysis constant of [Fe(EDTA)(H2O)]− and the formation constants of the complexes formed in solution were calculated using the non-linear least-squares program MINIQUAD-75. The concentration distributions of the various complex species were evaluated as a function of pH. The thermodynamic parameters ΔH 0 and ΔS 0, calculated from the temperature dependence of the equilibrium constants, were determined for the Fe(EDTA)–uracil complex. The effect of dioxane as a solvent on the protonation constant of uracil, hydrolysis constants of [Fe(EDTA)(H2O)]−, and the formation constants of the Fe(EDTA)–uracil complex are discussed.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Cairo University, Cairo, Egypt

    Ahmed A. El-Sherif, Mohamed M. Shoukry, Wafaa M. Hosny & Mohamed G. Abd-Elmoghny

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  1. Ahmed A. El-Sherif
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  2. Mohamed M. Shoukry
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  3. Wafaa M. Hosny
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  4. Mohamed G. Abd-Elmoghny
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Correspondence to Mohamed M. Shoukry.

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El-Sherif, A.A., Shoukry, M.M., Hosny, W.M. et al. Complex Formation Equilibria of Unusual Seven-Coordinate Fe(EDTA) Complexes with DNA Constituents and Related Bio-relevant Ligands. J Solution Chem 41, 813–827 (2012). https://doi.org/10.1007/s10953-012-9833-4

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