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Solubility Parameter of Gatifloxacin and Its Correlation with Antibacterial Activity

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Abstract

The solubility parameter of gatifloxacin was calculated theoretically by Fedors’ method and also determined experimentally using the standard solubility method. The molar volume of gatifloxacin was determined experimentally by the flotation method. Three solvents, ethyl acetate, propylene glycol and water were used to prepare nine binary mixtures having different solubility parameter values varying from 8.9 to 23.4 H. The δ 2 solubility parameter of gatifloxacin was found to be 12.4 H. The cumulative transport of gatifloxacin from the binary solvent mixtures (ethyl acetate–propylene glycol and propylene glycol–water) exhibited an inverse parabolic relationship to the solubility parameter of the solvent mixtures. Transport studies revealed that the extent of gatifloxacin rejection from solvent mixtures was dependent on its solubility parameter and system composition. In the selected organisms (bacteria), a minimum zone of inhibition was observed in a solvent mixture having the solubility parameter nearest to the solubility parameter of gatifloxacin. Two models were employed for the evaluation of the antibacterial activity of gatifloxacin in binary mixtures.

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Authors and Affiliations

  1. Bapuji Pharmacy College, Davangere, Karnataka, India

    Manjunath Kopparam, C. V. S. Subrahmanyam, Thimmasetty Juturu & Nitin Kumar S.

  2. Sree Siddaganga College of Pharmacy, Tumkur, Karnataka, India

    Manjunath Kopparam

  3. G. R. College of Pharmacy, Bachupally, Hyderabad, Andhra Pradesh, India

    C. V. S. Subrahmanyam

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  1. Manjunath Kopparam
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  2. C. V. S. Subrahmanyam
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  3. Thimmasetty Juturu
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  4. Nitin Kumar S.
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Correspondence to Manjunath Kopparam.

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Kopparam, M., Subrahmanyam, C.V.S., Juturu, T. et al. Solubility Parameter of Gatifloxacin and Its Correlation with Antibacterial Activity. J Solution Chem 41, 381–391 (2012). https://doi.org/10.1007/s10953-012-9803-x

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  • DOI: https://doi.org/10.1007/s10953-012-9803-x

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