Abstract
Ternary complex formation reactions were studied between vanadium(III), dipicolinic acid and small molecular weight blood serum components: lactic, oxalic, citric and ortophosphoric acids. The electromotive force measurement permitted us to determine the chemical speciation of the complexes formed. In the vanadium(III)–dipicolinic acid–lactic acid system the complexes detected were: V(dipic)(lac), V(dipic)(lac)(OH)− and V(dipic)(lac)\((\mathrm{OH})_{2}^{2-}\). In the vanadium(III)–dipicolinic acid–oxalic acid system the observed complexes were: V(dipic)(ox)−, V(dipic)(ox)(Hox)2− and V(dipic)\((\mathrm{ox})_{2}^{3-}\). In the vanadium(III)–dipicolinic acid–citric acid system the complexes V(dipic)(Hcit)−, V(dipic)(cit)2−, V(dipic)(cit)(OH)3−, V(dipic)(cit)\((\mathrm{OH})_{2}^{4-}\) and V(dipic)(cit)\((\mathrm{OH})_{3}^{5-}\) were detected. Finally in the vanadium(III)–dipicolinic acid–phosphoric acid system the complexes V(dipic)(H2PO4) and V(dipic)(HPO4)− were observed. The UV-vis spectra allowed us to perform a qualitative characterization of the complexes formed in aqueous solution.
Similar content being viewed by others
References
Papaioannou, A., Manos, M., Karkabounas, S., Liasko, R., Evangelou, A.M., Correia, I., Kalfakakou, V., Costa Pessoa, J., Kabanos, T.: Solid state and solution studies of a vanadium(III)–l-cysteine compound and demostration of its antimetastic, antioxidant and inhibition of neutral endopeptidase activities. J. Inorg. Biochem. 98, 959–968 (2004)
Thompson, K.H., Orvig, C.: Coordination chemistry of vanadium in metallopharmaceutical candidate compounds. Coord. Chem. Rev. 219–221, 1033–1053 (2001)
Shechter, Y., Goldwaser, I., Mironchik, M., Fridkin, M., Gefel, D.: Historic perspective and recent developments on the insulin-like actions of vanadium; toward developing vanadium-based drugs for diabetes. Coord. Chem. Rev. 237, 3–11 (2003)
Osińska-Królicka, I., Podsiadły, H., Bukietyńska, K., Zemanek-Zboch, M., Nowak, D., Suchoszek-Łukaniuk, K., Malicka-Błaszkiewicz, M.: Vanadium(III) complexes with l-cysteine-stability, speciation and the effect on actin in hepatoma morris 5123 cells. J. Inorg. Biochem. 98, 2087–2098 (2004)
Crans, D.C., Smee, J.J., Gaidamauskas, E., Luquin, Y.: The chemistry and biochemistry of vanadium and the biological activities exerted by vanadium compounds. Chem. Rev. 104, 849–902 (2004)
Kanamori, K.: Structures and properties of multinuclear vanadium(III) complexes: seeking a clue to understand the role of vanadium(III) in ascidians. Coord. Chem. Rev. 237, 147–161 (2003)
Kanamori, K., Kyoto, A., Fujimoto, K., Nagata, K., Suzuki, H., Okamoto, K.I.: Synthesis, structures, and properties of vanadium(III) complexes with the hexadentate ligand, tetramethylenediamine-N,N,N′,N′-tetraacetate, N,N′-bis(2-pyridylmethyl)-1,2-ethanediamine-N,N′-diacetate, and N,N′-bis(2-pyridylmethyl)-1,3-propanediamine-N,N′-diacetate. Bull. Chem. Soc. Jpn. 74, 2113–2118 (2001)
Lubes, V.: Vanadium(III) complexes with picolinic acid and dipicolinic acid in aqueous solution. J. Solution Chem. 34, 899–915 (2005)
Kiss, E., Petrohán, K., Sanna, D., Garribba, E., Micera, G., Kiss, T.: Solution speciation and spectral studies on oxovanadium(IV) complexes of pyridinecarboxylic acids. Polyhedron 19, 55–61 (2000)
Buglyó, P., Crans, D.C., Nagy, E.M., Lindo, R.L., Yang, L., Smee, J.J., Jin, W., Har Chi, L., Godzala, M.E. III, Willsky, G.R.: Aqueous chemistry of the vanadiumIII (VIII) and the VIII–dipicolinate systems and a comparison of the effect of three oxidation states of vanadium compounds on diabetic hyperglycemia in rats. Inorg. Chem. 44, 5416–5427 (2005)
Kiss, T., Jakusch, T., Kilyen, M., Kiss, E., Lakatos, A.: Solution speciation of bioactive Al(III) and VO(IV) complexes. Polyhedron 19, 2389–2401 (2000)
Brito, F., Goncalves, J.M.: Complejos de vanadio(III) 2. Potencial normal del sistema VO2+/V3+ [25 °C,(K)Cl 3 M]. An. Fis. Quím. 78, 104–105 (1982)
Brito, F., Goncalves, J.: Proyecto No. S1-1228. CONICIT. Caracas, Venezuela (1981)
Sillén, L.G., Warnqvist, B.: High-speed computers as a supplement to graphical methods. VI. A strategy for two-level letagrop adjustment of common and “group” parameters: features that avoid divergence. Ark. Kemi 31, 315–339 (1969)
Alderighi, L., Gans, P., Ienco, A., Peters, D., Sabatini, A., Vacca, A.: Hyperquad simulation and speciation (HySS): a utility program for the investigation of equilibria involving soluble and partially soluble species. Coord. Chem. Rev. 184, 311–318 (1999)
Khalil, M.M., Radalla, A.M., Mohamed, A.G.: Potentiometric investigation on complexation of divalent transition metal ions with some zwitterionic buffers and triazoles. J. Chem. Eng. Data 54, 3261–3272 (2009)
Meier, R., Boddin, M., Mitzenheim, S., Schmid, V., Schonherr, T.: Elucidation of V(III) complex coordination numbers by electronic spectra. J. Inorg. Biochem. 69, 249–252 (1998)
Bricual, J., Lubes, V., Araujo, M.L., Brito, F.: Vanadium(III) complexes in aqueous solution with the dicarboxylic oxalic, malonic and succinic acids. J. Chil. Chem. Soc. 49, 285–288 (2004)
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Da Costa, F., Lubes, G., Rodríguez, M. et al. Study of the Ternary Complex Formation Between Vanadium(III), Dipicolinic Acid and Small Blood Serum Bioligands. J Solution Chem 40, 106–117 (2011). https://doi.org/10.1007/s10953-010-9623-9
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10953-010-9623-9