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Spectroscopic Studies on the Molecular Complex of the Drug Atenolol with Iodine

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Abstract

Spectroscopic and spectrofluorimetric studies were made of the interaction between the drug atenolol and iodine. The interaction was found to proceed through the initial formation of a charge transfer (CT) complex as an intermediate species. The product of this interaction has been isolated and characterized using UV-Vis, FT-IR and Raman spectroscopic techniques. Formation of the triodide \(\mathrm{I}_{3}^{-}\) species was confirmed by its electronic and Raman spectra. Peaks appeared in Raman spectrum of the isolated product at 153, 102 and 85 cm−1 that are assigned to ν as(I-I), ν s(I-I) and \(\delta(\mathrm{I}_{3}^{-})\) respectively, which confirmed the presence of the \(\mathrm{I}_{3}^{-}\) ion. The stoichiometry of the complex was found to be 1:2. The rate of their reaction has been measured as a function of time and solvent. Pseudo-first-order rate constants for the reaction were measured at various temperatures and the thermodynamic activation parameters (ΔG #,ΔS # and ΔH #) were computed. Preliminary fluorescence quenching studies indicated that the interaction between atenolol and iodine is spontaneous and proceeds through a CT complex, and the quenching of fluorescence of atenolol by iodine increases as the extent of such complexation increases

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  1. Department of Chemistry, Gandhigram Rural University, Gandhigram, 624 302, India

    M. Pandeeswaran & K. P. Elango

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  1. M. Pandeeswaran
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  2. K. P. Elango
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Correspondence to K. P. Elango.

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Dedicated to the memory of Prof. G. Karthikeyan.

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Pandeeswaran, M., Elango, K.P. Spectroscopic Studies on the Molecular Complex of the Drug Atenolol with Iodine. J Solution Chem 38, 1558–1572 (2009). https://doi.org/10.1007/s10953-009-9467-3

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  • DOI: https://doi.org/10.1007/s10953-009-9467-3

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