Skip to main content
SpringerLink
Log in

Synthesis, Electrochemical Characteristics of [Ni(phen)(H2O)4]SO4⋅2H2O and Its Interaction Mechanism with DNA

  • Published:
Journal of Solution Chemistry Aims and scope Submit manuscript

Abstract

A polypyridyl nickel complex of [Ni(phen)(H2O)4]SO4⋅2H2O (phen = 1,10-phenanthroline) was synthesized and characterized by X-ray diffraction and IR spectroscopy. The results indicated that the central nickel ion is in a distorted octahedral geometry coordinated by two nitrogen atoms from 1,10-phenanthroline and four water molecules. The crystal data for this complex are: a=8.8797(18) Å, b=18.468(4) Å, c=22.081(4) Å, α=90°, β=90°, γ=90°, R 1=0.0533, and wR 2=0.2095. Electrochemical experiments showed that the complex could be reoxidized at a gold electrode under the precondition of electrolysis stripping. According to the results of cyclic voltammetry and coulometry, an electrochemical reaction mechanism was proposed. The DNA binding properties of the complex were further investigated by electronic absorption spectrophotometry and electrochemistry. The binding constant and the binding mode between the two species were estimated based on the spectroscopic and electrochemical results.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Yamanaka, T.: In: Otsuka, S., Yamanaka, T. (eds.) Metalloproteins, p. 285. Elsevier, Amsterdam (1998)

    Google Scholar 

  2. Matkar, S.S., Wrischnik, L.A., Jones, P.R., Hellmann-Blumberg, U.: Two closely related nickel complexes have different effects on DNA damage and cell viability. Biochem. Biophys. Res. Commun. 343, 754–761 (2006)

    Article  CAS  Google Scholar 

  3. Kawanishi, S., Inoue, S., Oikawa, S., Yamashita, N., Toyokuni, S., Kawanishi, M., Nishino, K.: Oxidative DNA damage in cultured cells and rat lungs by carcinogenic nickel compounds. Free Radic. Biol. Med. 31, 108–116 (2001)

    Article  CAS  Google Scholar 

  4. Volkmer, D., Hommerich, B., Griesar, K., Haase, W., Krebs, B.: Dinuclear nickel(II) complexes as models for the active site of urease. Inorg. Chem. 35, 3792–3803 (1996)

    Article  CAS  Google Scholar 

  5. Schäfer, S., Ott, I., Gust, R., Sheldrick, W.S.: Influence of the polypyridyl (pp) ligand size on the DNA binding properties, cytotoxicity and cellular uptake of organoruthenium(II) complexes of the type [(6-C6Me6)Ru(L)(pp)]n+ [L = Cl, n=1; L = (NH2)2CS, n=2]. Euro. J. Inorg. Chem. 3034–3046 (2007)

  6. Song, G.W., Li, L., Liu, L.M., Fang, G.R., Lu, S.F., He, Z.K., Zeng, Y.E.: Fluorometric determination of DNA using a new ruthenium complex Ru(bpy)2PIP(V) as a nucleic acid probe. Anal. Sci. 7, 757–759 (2002)

    Article  Google Scholar 

  7. Scharwitz, M., Ott, I., Geldmacher, Y., Gust, R., Sheldrick, W.R.: Cytotoxic half-sandwich rhodium(III) complexes: Polypyridyl ligand influence on their DNA binding properties and cellular uptake. J. Organomet. Chem. 693, 2299–2309 (2008)

    Article  CAS  Google Scholar 

  8. Wang, Q.X., Jiao, K., Sun, W., Jian, F.F., Hu, X.: Binding of an oxo-bridged dinuclear iron(III) complex{[Fe(phen)(H2O)3]2O}(SO4)2 to DNA and its recognition of single- and double-stranded DNA as determined by electrochemical studies. Eur. J. Inorg. Chem. 1838–1845 (2006)

  9. Millan, K.M., Angela, S., Susan, R.M.: Voltammetric DNA biosensor for cystic fibrosis based on a modified carbon paste electrode. Anal. Chem. 66, 2943–2948 (1994)

    Article  CAS  Google Scholar 

  10. Reichman, M.E., Rice, S.A., Thomas, C.A., Doty, P.A.: A further examination of the molecular weight and size of desoxypentose nucleic acid. J. Am. Chem. Soc. 76, 3047–3053 (1954)

    Article  Google Scholar 

  11. Kumar, C.V., Asuncion, E.H.: DNA binding studies and site selective fluorescence sensitization of an anthryl probe. J. Am. Chem. Soc. 115, 8547–8553 (1993)

    Article  CAS  Google Scholar 

  12. Sheldrick, G.M.: SADABS, Program for Empirical Absorption Correction of Area Detector Data. University of Gottingen, Gottingen (1996)

    Google Scholar 

  13. Sheldrick, G.M.: SHELXS-97, program for x-ray crystal structure solution. University of Gottingen, Gottingen (1997)

    Google Scholar 

  14. Cromer, D.T., Waber, J.T.: International Tables tor X-Ray Crystallography. Kynock Press, Birmingham (1974)

    Google Scholar 

  15. Walczak, M.M., Flynn, N.T.: Spectroelectrochemical study of the generation of tris-(1,10-phenanthroline) iron(II/III) from m-oxo-bis[aquabis(1,10-phenanthroline) iron(III). J. Electroanal. Chem. 441, 43–49 (1998)

    Article  CAS  Google Scholar 

  16. Bard, A.J., Faulkner, L.R.: Electrochemical Methods: Fundamentals and Applications. Wiley, New York (1980)

    Google Scholar 

  17. Henne, B.J., Bartak, D.E.: Metal-vapor synthesis and electrochemistry of bis(bipyridyl)nickel(0). Inorg. Chem. 23, 369–373 (1984)

    Article  CAS  Google Scholar 

  18. Wang, Q.X., Jiao, K., Liu, F.Q., Yuan, X.L., Sun, W.: Spectroscopic, viscositic and electrochemical studies of DNA interaction with a novel mixed-ligand complex of nickel (II) that incorporates 1-methylimidazole and thiocyanate groups. J. Biochem. Biophys. Methods 70, 427–433 (2007)

    Article  CAS  Google Scholar 

  19. Jiao, K., Wang, Q.X., Sun, W., Jian, F.F.: Synthesis, characterization and DNA-binding properties of a new cobalt(II) complex: Co(bbt)2Cl2. J. Inorg. Biochem. 99, 1369–1375 (2005)

    Article  CAS  Google Scholar 

  20. Tang, S.P., Hou, L., Mao, Z.W., Ji, L.N.: Synthesis, crystal structures, DNA binding and oxidative cleavage studies of copper(II) complexes of N2S2 tetradentate ligands. Polyhedron 28, 586–592 (2009)

    Article  CAS  Google Scholar 

  21. Zhang, Q.L., Liu, J.G., Chao, H., Xue, G.Q., Ji, L.N.: DNA-binding and photocleavage studies of cobalt(III) polypyridyl complexes: [Co(phen)2IP]3+ and [Co(phen)2PIP]3+. J. Inorg. Biochem. 83, 49–55 (2001)

    Article  CAS  Google Scholar 

  22. Navarro, M., Cisneros-Fajardo, E.J., Sierralta, A., Fernández-Mestre, M., Silva, P., Arrieche, D., Marchán, E.: Design of copper DNA intercalators with leishmanicidal activity. J. Biol. Inorg. Chem. 8, 401–408 (2003)

    CAS  Google Scholar 

  23. Pasternack, R.F., Gibbs, E.J., Villafranca, J.J.: Interactions of porphyrins with nucleic acids. Biochemistry 22, 2406–2414 (1983)

    Article  CAS  Google Scholar 

  24. Scharwitz, M.A., Ott, I., Geldmacher, Y., Gust, R., Sheldrick, W.S.: Otoxic half-sandwich rhodium(III) complexes: polypyridyl ligand influence on their DNA binding properties and cellular uptake. J. Organomet. Chem. 693, 2299–2309 (2008)

    Article  CAS  Google Scholar 

  25. Jing, B.W., Zhang, M.H., Shen, T.: [Ruthenium(II)(bpy)2L]2+, where L are imidazo[f]-1,10-phenanthrolines: synthesis, photophysics and binding with DNA. Spectrochim. Acta. A 60, 2635–2641 (2004)

    Article  Google Scholar 

  26. Sherman, S.E., Gibson, D., Wang, A.H.J., Lippard, S.J.: Crystal and molecular structure of cis-[Pt(NH3)2[d(pGpG)]], the principal adduct formed by cis-diamminedichloroplatinum(II) with DNA. J. Am. Chem. Soc. 110, 7368–7381 (1988)

    Article  CAS  Google Scholar 

  27. Zhou, J.Y., Li, Q.X., Wang, L.J., Liao, Z.R., Xu, H.B.: DNA damage by copper(II) complexes: coordination-structural dependence of reactivities. J. Inorg. Biochem. 75, 233–240 (1999)

    Article  Google Scholar 

  28. Wolfe, A., Shimer-Jr, G.H., Meehan, T.: Polycyclic aromatichydrocarbons physically intercalate into duplex regions of denatured DNA. Biochemistry 26, 6392–6396 (1987)

    Article  CAS  Google Scholar 

  29. Wu, J.Z., Zhou, Z.Y., Ji, L.N.: Structure of [Ru(phen)3](ClO4)2⋅(C2H5)2O. Cryst. Res. Technol. 36, 101–105 (2001)

    Article  CAS  Google Scholar 

  30. Mudasir, Yoshioka, N., Inoue, H.: DNA binding of iron(II) mixed-ligand complexes containing 1,10-phenanthroline and 4,7-diphenyl-1,10-phenanthroline. J. Inorg. Biochem. 77, 239–247 (1999)

    Article  CAS  Google Scholar 

  31. Mello, L.D., Pereira, R.M.S., Sawaya, A.C.H.F., Eberlin, M.N., Kubot, L.T.: Electrochemical and spectroscopic characterization of the interaction between DNA and Cu(II)–naringin complex. J. Pharm. Biomed. 45, 706–713 (2007)

    Article  CAS  Google Scholar 

  32. Zhang, Y.Z., Cai, Y.J., Su, S., Ni, Y.H.: Electrochemical studies of oxidation of lomefloxacin and interaction with calf thymus DNA at nano-SnO2/DHP modified electrode. Electroanal. 18, 1479–1484 (2006)

    Article  CAS  Google Scholar 

  33. Arjmand, F., Mohani, B., Parveen, S.: New dihydro O,O′-bis(salicylidene) 2,2′ aminobenzothiazolyl borate complexes: kinetic and voltammetric studies of dimethyltin copper complex with guanine, adenine, and calf thymus DNA. Bioinorg. Chem. Appl. 2006, 1–10 (2006)

    Article  Google Scholar 

  34. Xu, Z.H., Chen, F.J., Xia, P.X., Liu, X.H., Zeng, Z.Z.: Synthesis, characterization, and DNA-binding properties of the cobalt(II) and nickel(II) complexes with salicylaldehyde 2-phenylquinoline-4-carboylhydrazone. J. Photochem. Photobiol. Chem. 196, 77–83 (2008)

    Article  CAS  Google Scholar 

  35. Laviron, E.: : General expression of the linear potential sweep voltammogram in the case of diffusionless electrochemical systems. J. Electroanal. Chem. 101, 19–28 (1979)

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemistry and Environmental Science, Zhangzhou Normal University, Zhangzhou, 363000, China

    Qingxiang Wang, Hongxu Guo, Shunxing Li, Feng Gao & Danfeng Fang

  2. Fujian Province University Key Laboratory of Analytical Science, Zhangzhou Normal University, Zhangzhou, 363000, China

    Qingxiang Wang & Shunxing Li

Authors
  1. Qingxiang Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hongxu Guo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Shunxing Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Feng Gao
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Danfeng Fang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Qingxiang Wang.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wang, Q., Guo, H., Li, S. et al. Synthesis, Electrochemical Characteristics of [Ni(phen)(H2O)4]SO4⋅2H2O and Its Interaction Mechanism with DNA. J Solution Chem 38, 1085–1095 (2009). https://doi.org/10.1007/s10953-009-9425-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10953-009-9425-0

Keywords

Search

Navigation