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Doxorubicin Embedded Polyvinylpyrrolidone-Coated Fe3O4 Nanoparticles for Targeted Drug Delivery System

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Abstract

In novel drug delivery systems, polymeric materials are combined with drugs or active agents where the drug is released in the presence of external stimuli like pH, temperature, magnetic field, etc. Magnetic drug delivery systems can be used in cancer treatment. Fe3O4 nanoparticles have been applied in biomedical applications due to their biocompatibility and biodegradability properties. In this study, magnetic nanocomposites were developed and demonstrated to be responsive to the magnetic field. Fe3O4 nanoparticles were synthesized by the co-precipitation method. The synthesized nanoparticles were modified by (3-aminopropyl) triethoxysilane (APTES) (Fe3O4@SiO2) and coated with polyvinylpyrrolidone (PVP). Magnetic properties of the nanoparticles and hydrogel were characterized by vibrating sample magnetometer (VSM). In the present study, doxorubicin (DOX) is used as a cancer drug, loaded in the nanocomposite. The attachment of Dox, PVP to the Fe3O4 nanoparticles was confirmed by FTIR analysis. Different characterizations were carried out, such as swelling measurements, scanning electron microscopy (SEM), and X-ray diffraction (XRD) as well as rheological parameters. The drug release from the untreated and treated nanoparticles was investigated in two different pHs by using UV–Vis. Our findings show that the rate of drug release is higher at pH = 5 than pH = 7.4. Altogether, the magnetic nanocomposite hydrogels are promising products for magnetically targeted drug delivery systems.

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Acknowledgements

The authors are grateful to Radiation Application Research School, Foundation of Nuclear Science and Technology Research Institute and Golestan University for supporting this research work. We are also grateful to Dr. Naser Zarsav for his valuable comments and thoroughly editing the manuscript.

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Authors and Affiliations

  1. Polymer Engineering Department, Faculty of Engineering, Golestan University, Gorgan, Iran

    Taraneh Ehteshamzadeh & Mehdi Ghaffari

  2. Radiation Application Research School, Nuclear Science and Technology Research Institute, Tehran, Iran

    Saeed Kakaei

  3. Material and Nuclear Fuel Research School, Nuclear Science and Technology Research Institute, Tehran, Iran

    Ali Reza Khanchi

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  1. Taraneh Ehteshamzadeh
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  2. Saeed Kakaei
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  4. Ali Reza Khanchi
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Correspondence to Mehdi Ghaffari.

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Ehteshamzadeh, T., Kakaei, S., Ghaffari, M. et al. Doxorubicin Embedded Polyvinylpyrrolidone-Coated Fe3O4 Nanoparticles for Targeted Drug Delivery System. J Supercond Nov Magn 34, 3345–3360 (2021). https://doi.org/10.1007/s10948-021-05952-5

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  • DOI: https://doi.org/10.1007/s10948-021-05952-5

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