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NMR investigation on the interaction of β-cyclodextrin and ampicillin

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Abstract

The penetration of ampicillin molecule into the β-cyclodextrin cavity in aqueous solution is studied by 1 H NMR, 2D COSY and ROESY spectroscopy. Obtained data suggest that the phenyl moiety of ampicillin is included inside the hydrophobic cavity of β-cyclodextrin molecule in the solution, and the mode and depth of this inclusion is confirmed on the basis of 2D ROESY spectral data.

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Authors and Affiliations

  1. Department of Chemistry, Aligarh Muslim University, Aligarh, 202 002, UP, India

    S. K. Upadhyay & S. M. Ali

Authors
  1. S. K. Upadhyay
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  2. S. M. Ali
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Correspondence to S. K. Upadhyay.

Additional information

The text was submitted by the authors in English. Zhurnal Strukturnoi Khimii, Vol. 51, No. 5, pp. 1003–1006, September–October, 2010.

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Upadhyay, S.K., Ali, S.M. NMR investigation on the interaction of β-cyclodextrin and ampicillin. J Struct Chem 51, 972–975 (2010). https://doi.org/10.1007/s10947-010-0149-1

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  • DOI: https://doi.org/10.1007/s10947-010-0149-1

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