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Kinetic analysis of pH influence on the fluorescein release from chitosan-coated mesoporous silica nanoparticles

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Abstract

The development of drug delivery systems that are able to respond to the different pH gradients found in the human body is a research field of vast scientific and technological interests. With such a responsive system, a specific pH condition can be used as a stimulus to trigger the local drug-releasing, increasing the efficiency of treatments in comparison to the traditional ones of systemic drug administration. In this study, a responsive drug nanocarrier to acid pH was produced by coating mesoporous silica nanoparticles with an outer chitosan layer that was covalently bonded to the nanoparticle. Fluorescein dye (FL) was loaded into the nanocarrier and used as a spectroscopic probe to evaluate the kinetics of release in buffered solutions with pH 6.0, 7.2 and 8.0. The kinetics analysis using mathematical models demonstrated higher rates of release in pH 6.0 than in pH 7.2 or 8.0. However, the experimental procedure used to load the dye into the nanocarrier had a huge influence on the kinetic mechanisms of delivering. When the dye was loaded into the nanocarrier before the chitosan coating had been made, the FL release was sustained and controlled through a Fickian's transport mechanism. When the dye was loaded after the nanocarrier coating a burst release effect was observed in every pH evaluated, which indicated that the dye was loaded only in the external coating of CS and did not inside of the silica mesopores.

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Acknowledgements

Authors are thankful to Prof. Vera R. L. Constantino (IQ-USP) for providing the use of the equipments for X-ray diffractometry analysis and thermogravimetric and to Dr. Ricardo Couto (IQ-USP) for his support on the acquiring the TGA and N2 physisorption data. M. A. Bizeto is thankful to the financial support from the Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) (Grant Nos. 2011/50318-1 and 2019/05467-0). M. Ferreira is thankful to the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES—Finance Code 001).

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  1. Laboratório de Materiais Híbridos, Departamento de Química, Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo, Rua São Nicolau, 210, Diadema, SP, CEP: 09913-030, Brazil

    Mariana Mendonça Ferreira & Marcos Augusto Bizeto

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  1. Mariana Mendonça Ferreira
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  2. Marcos Augusto Bizeto
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Correspondence to Marcos Augusto Bizeto.

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Ferreira, M.M., Bizeto, M.A. Kinetic analysis of pH influence on the fluorescein release from chitosan-coated mesoporous silica nanoparticles. J Porous Mater 27, 1077–1086 (2020). https://doi.org/10.1007/s10934-020-00885-1

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