Mesoporous silica submicron particles (MCM-41) incorporating nanoscale Ag: synthesis, characterization and application as drug delivery coatings
Mesoporous silica particles (MCM-41) decorated with Ag nanoparticles were prepared by the template ion exchange (TIE) method. The properties of the synthesized material were investigated by several techniques, including the nitrogen sorption measurements, X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and Fourier Transform Infrared Spectroscopy (FTIR). Moreover, the degradability of the particles was tested in simulated body fluid (SBF) in order to evaluate the degradation rate of the material. The silica particles were loaded with different Ag concentrations but no structural changes were observed in the ordered mesoporosity. Already after 1 day of immersion in SBF most of the silver particles were released and partial degradation of the silica particles was observed. Ibuprofen was loaded into the Ag containing MCM-41 particles in order to evaluate their drug up-take/release capability. Silver and silicon ion release was quantified with inductively coupled plasma optical emission spectroscopy (ICP-OES). The novel silver doped MCM-41 particles were used as a functional coating on bioactive glass (BG) based scaffolds intended for bone tissue engineering application.
KeywordsSilica Mesoporous particles Silver Drug delivery Scaffolds
This manuscript is based on the doctoral thesis of E. Boccardi, University of Erlangen-Nuremberg, Germany. AMB thanks Talent-Hub Program funded by the Junta de Andalucía and the European Commission under the Co-funding of the 7th Framework Program in the People Program (Marie Curie Special Action). Authors also acknowledge the Laboratory for Nanoscopies and Spectroscopies (LANE) at the ICMS for the TEM facilities and for CG for BET measurements. LL acknowledges funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie Grant Agreement No. 657264.
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