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The synergistic cooperation between MCM-41 and azithromycin: a pH responsive system for drug adsorption and release

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Abstract

The capability of MCM-41 silica for accepting and delivering poorly soluble azithromycin (AZT) in water is reported as robust drug delivery system. This property has been evidenced by using two MCM-41 samples with different pore sizes as hosts of AZT. The choice of this macrolide antibiotic is due not only to its low bioavailability but also to its molecular size which lies in the range of pore diameter of MCM-41s. The drug was loaded inside the pore voids of the mesoporous when MCM-41 was stirred at AZT solution, based on XRD, Nitrogen adsorption–desorption isotherms, TGA analysis data and FT-IR spectroscopy. The amount of AZT stored inside the pores of MCM-41 s was between 22 and 25 wt%. The loaded drug was released in different rates from the particles by changing the pH (1.7 and 7.4) to give a smart pH-responsive carrier system. The drug release kinetics was fitted to Korsmeyer–Peppas and Higuchi models which indicated that the rate of drug release was controlled by the diffusion of the drug. The result of the present study confirms that the controlled adsorption and liberation of AZT may improve the oral bioavailability of poor water soluble AZT. This study demonstrates the feasibility of designing reliable drug delivery systems by appropriate choice of the matrix and the organic molecule. In general, MCM-41 is a promising matrix for AZT adsorption with different application from drug delivery to wastewater filtration.

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Acknowledgements

The Ministry of Science, Research and Technology of Iran is acknowledged for partial financial assistance of this work.

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Authors and Affiliations

  1. Department of Physical Chemistry, School of Chemistry, College of Science, University of Tehran, Tehran, Iran

    Majid Hamzehloo & Jahangir Karimi

  2. Nano & Organic Synthesis Lab., Chemistry & Chemical Engineering Research Center of Iran, Pajoohesh Blvd., km 17, Karaj Hwy, Tehran, 14968-13151, Iran

    Kioumars Aghapoor, Hani Sayahi & Hossein Reza Darabi

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  1. Majid Hamzehloo
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  2. Jahangir Karimi
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  5. Hossein Reza Darabi
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Correspondence to Hossein Reza Darabi.

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Hamzehloo, M., Karimi, J., Aghapoor, K. et al. The synergistic cooperation between MCM-41 and azithromycin: a pH responsive system for drug adsorption and release. J Porous Mater 25, 1275–1285 (2018). https://doi.org/10.1007/s10934-017-0538-3

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