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Porous chitosan-based adhesive patch filled with poly(l-3,4-dihydroxyphenylalanine) as a transdermal drug-delivery system

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Abstract

Bioadhesives have been widely used on surgical areas for more than 50 years. Despite their numerous advantages, drawbacks such as cytotoxicity and low efficiency of transdermal drug delivery have limited their applications. Consequently, bioadhesives are mainly used during emergencies. To improve the physical properties of bioadhesive materials, poly(l-3,4-dihydroxyphenylalanine) or poly(l-DOPA) was synthesized and used to fill 2 kinds of porous chitosan patches (high and medium molecular weight). Bioaddisive and patch properties such as bond strength, drug-delivery efficiency, morphology, cytotoxicity, and histology were characterized. We ascertained that the optimal combination for high bond strength was 77.9 % polymethacrylic acid (PMA, molecular weight: 9,500 Da) and 22.1 % l-DOPA. Drug release was 1.5 times faster from the poly(l-DOPA)-filled chitosan patch of medium molecular weight than from the high molecular weight patch. Further, the medium molecular weight chitosan patch was more efficient at wound healing than commercial glue. These results indicate that chitosan-based materials filled with poly(l-DOPA) can be used as adhesive patches in various fields.

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Acknowledgments

This study was supported by a grant of the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea. (A110216).

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Authors and Affiliations

  1. Department of Biomedical Engineering and Healthcare Industry Research Institute, College of Medicine, Kyung Hee University, Dongdaemun-gu, Seoul, 130-701, Republic of Korea

    Ji Hye Kim, Jin Ik Lim & Hun-Kuk Park

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  1. Ji Hye Kim
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  2. Jin Ik Lim
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  3. Hun-Kuk Park
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Correspondence to Jin Ik Lim or Hun-Kuk Park.

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Kim, J.H., Lim, J.I. & Park, HK. Porous chitosan-based adhesive patch filled with poly(l-3,4-dihydroxyphenylalanine) as a transdermal drug-delivery system. J Porous Mater 20, 177–182 (2013). https://doi.org/10.1007/s10934-012-9587-9

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  • DOI: https://doi.org/10.1007/s10934-012-9587-9

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