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Synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones using ZrOCl2/mont K10 under microwave assisted solvent-free conditions

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Abstract

ZrOCl2·8H2O supported on montmorillonite K10 (ZrOCl2/mont K10) catalyzed Biginelli reaction under solvent-free conditions is reported. The catalysts were characterized by XRD, FTIR, BET surface area analysis, and thermogravimetric analysis. The activity of montmorillonite K10, montmorillonite KSF, ZrOCl2·8H2O, SO4 2−/ZrO2, and ZrOCl2/mont K10s was investigated by Biginelli reaction of benzaldehyde, ethylacetoacetate and urea. The reactions were carried out by addition of ZrOCl2/mont K10 to a mixture of aldehyde, ethylacetoacetate and urea/thiourea with thorough stirring in the absence of solvent under conventional heating or microwave irradiation to prepare 3,4-dihydropyrimidin-2(1H)-one/thione derivatives at 80 °C in good yields.

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Acknowledgments

This work is funded by the Department of Science and Technology, New Delhi, India, under Fast Track Scheme for Young Scientists (Project No. SR/FTP/CS-11/2006).

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Authors and Affiliations

  1. Department of Chemistry, Indian Institute of Technology Madras, Chennai, 600036, India

    B. Vijayakumar & G. Ranga Rao

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  1. B. Vijayakumar
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  2. G. Ranga Rao
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Correspondence to B. Vijayakumar.

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Vijayakumar, B., Ranga Rao, G. Synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones using ZrOCl2/mont K10 under microwave assisted solvent-free conditions. J Porous Mater 19, 491–497 (2012). https://doi.org/10.1007/s10934-011-9498-1

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