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Role of ionic liquids on stabilization of therapeutic proteins and model proteins

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Abstract

Ionic liquids (ILs) exhibit potential as excipients to stabilize proteins in solutions. This mini-review is not a detailed reference book on ILs, rather a brief overview of the main achievements published in the literature on their effect on protein aggregation, unfolding, structural and thermal stability, and activity. The main focus of the manuscript is three widely studied groups of ionic liquids: imidazolium-, cholinium- and alkylammonium-based and their effect on the model and therapeutic proteins.

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  1. Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev Str. 9, 1113, Sofia, Bulgaria

    Maya Guncheva

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Guncheva, M. Role of ionic liquids on stabilization of therapeutic proteins and model proteins. Protein J 41, 369–380 (2022). https://doi.org/10.1007/s10930-022-10058-5

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