Journal of Pharmacokinetics and Pharmacodynamics

, Volume 41, Issue 5, pp 389–399 | Cite as

An immunology primer for computational modelers

  • William F. HawseEmail author
  • Penelope A. Morel
Original Paper


The immune system is designed to protect an organism from infection and damage caused by a pathogen. A successful immune response requires the coordinated function of multiple cell types and molecules in the innate and adaptive immune systems. Given the complexity of the immune system, it would be advantageous to build computational models to better understand immune responses and develop models to better guide the design of immunotherapies. Often, researchers with strong quantitative backgrounds do not have formal training in immunology. Therefore, the goal of this review article is to provide a brief primer on cellular immunology that is geared for computational modelers.


Computational modeling T cell B cell Antibody Signaling 



We greatly acknowledge grant support from the US National Institutes of Health (5T32AI089443-04).


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of ImmunologyUniversity of PittsburghPittsburghUSA

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