Journal of Pharmacokinetics and Pharmacodynamics

, Volume 41, Issue 5, pp 401–413 | Cite as

Modeling the T cell immune response: a fascinating challenge

  • Penelope A. MorelEmail author
  • James R. Faeder
  • William F. Hawse
  • Natasa Miskov-Zivanov
Review Paper


The immune system is designed to protect the organism from infection and to repair damaged tissue. An effective response requires recognition of the threat, the appropriate effector mechanism to clear the pathogen and a return to homeostasis with minimal damage to self-tissues. T cells play a central role in orchestrating the immune response at all stages of the response and have been the subject of intense study by both experimental immunologists and modelers. This review examines some of the more critical questions in T cell biology and describes the latest attempts to address those questions using approaches that combine mathematical modeling and experiments.


T cell Signaling Mathematical modeling Immune regulation 



JRF and NMZ acknowledge funding from NIH grant P41 GM103712 and NSF Expeditions in Computing Grant (award 0926181). WFH was supported by NIH Grant T32 AI089443.


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Penelope A. Morel
    • 1
    Email author
  • James R. Faeder
    • 2
  • William F. Hawse
    • 1
  • Natasa Miskov-Zivanov
    • 2
    • 3
  1. 1.Departments of ImmunologyUniversity of PittsburghPittsburghUSA
  2. 2.Departments of Computational and Systems BiologyUniversity of PittsburghPittsburghUSA
  3. 3.Computer Science DepartmentCarnegie Mellon UniversityPittsburghUSA

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