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Journal of Pharmacokinetics and Pharmacodynamics

, Volume 41, Issue 5, pp 523–536 | Cite as

Review on modeling anti-antibody responses to monoclonal antibodies

  • José David Gómez-Mantilla
  • Iñaki F. TrocónizEmail author
  • Zinnia Parra-Guillén
  • María J. Garrido
Review Paper

Abstract

Monoclonal antibodies (mAbs) represent a therapeutic strategy that has been increasingly used in different diseases. mAbs are highly specific for their targets leading to induce specific effector functions. Despite their therapeutic benefits, the presence of immunogenic reactions is of growing concern. The immunogenicity identified as anti-drug antibodies (ADA) production due to the continuous administration of mAbs may affect the pharmacokinetics (PK) and/or the pharmacodynamics (PD) of mAbs administered to patients. Therefore, the immunogenicity and its clinical impact have been studied by several authors using PK modeling approaches. In this review, the authors try to present all those models under a unique theoretical mechanism-based framework incorporating the main considerations related to ADA formation, and how ADA may affect the efficacy or toxicity profile of some therapeutic biomolecules.

Keywords

Monoclonal antibodies (mAb) Immunogenicity Anti-drug antibodies (ADA) Anti-antibodies PKPD modeling 

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • José David Gómez-Mantilla
    • 1
  • Iñaki F. Trocóniz
    • 1
    Email author
  • Zinnia Parra-Guillén
    • 2
  • María J. Garrido
    • 1
  1. 1.Department of Pharmacy and Pharmaceutical Technology, School of PharmacyUniversity of NavarraPamplonaSpain
  2. 2.Department of Clinical Pharmacy, School of PharmacyUniversity of BerlinBerlinGermany

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