Skip to main content
SpringerLink
Log in

Liposomal Nanocarriers-Loaded Poly(vinyl alcohol) (PVA)/Poly(ethylene glycol) (PEG) Hydrogels: Physico-mechanical Properties and Drug Release

  • Original Paper
  • Published:
Journal of Polymers and the Environment Aims and scope Submit manuscript

Abstract

The main objective of this research is to investigate how curcumin liposomal nanocarriers influence the drug release behaviour of PVA/PEG hydrogels in relation to physico-mechanical properties. For this purpose, optimal nanoliposomes from drug loading and release viewpoints, prepared by the thin-film hydration method, were incorporated into the hydrogel composition. Hydrogel samples were physically crosslinked using the freeze–thaw procedure. According to the dynamic laser scattering, atomic force microscopy and field-emission scanning electron microscopy observations, negative nanoliposomes with negative surface charges showed a spherical morphology with an average particle size of about 100 nm and narrow size distribution. The X-ray diffraction results revealed that adding nanoliposomes to the hydrogel increases the degree of PVA chains crystallinity, enhances tensile modulus and tensile strength of the hydrogel, while decreasing swelling and dehydration rates. SEM micrographs observation displayed that the porosity in the hydrogel structure in the presence of nanoliposomes increases. Nevertheless, in agreement with physical properties, drug release from nanoliposome-in-hydrogel is slower and more controlled as compared to that from free curcumin hydrogel, especially in the early stages. The MTT assay results indicated that although all hydrogel samples are non-toxic, human foreskin fibroblast cell proliferation on hydrogel in the presence of curcumin-loaded nanoliposomes has improved somewhat.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10
Fig. 11
Fig. 12
Fig. 13
Fig. 14
Fig. 15

Similar content being viewed by others

References

  1. Kamoun EA, Kenawy ES, Chen X (2017) J Adv Res 8:217

    CAS  PubMed  PubMed Central  Google Scholar 

  2. Mihajlovic M, Mihajlovic M, Dankers PYW, Masereeuw R, Sijbesma RP (2019) Macromol Biosci 19:e1800173

    PubMed  Google Scholar 

  3. Onaciu A, Munteanu RA, Moldovan AI, Moldovan CS, Berindan-Neagoe I (2019) Pharmaceutics 11:432

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Karimi S, Bagher Z, Najmoddin N, Simorgh S, Pezeshki-Modaress M (2021) Int J Biol Macromol 167:796

    CAS  PubMed  Google Scholar 

  5. Peers S, Alcouffe P, Montembault A, Ladavière C (2020) Carbohydr Polym 229:115532

    CAS  PubMed  Google Scholar 

  6. Hemmingsen LM, Giordani B, Pettersen AK, Vitali B, Basnet P, Skalko-Basnet N (2021) Carbohydr Polym 262:117939

    CAS  PubMed  Google Scholar 

  7. Sato T, Uchida R, Tanigawa H, Uno K, Murakami A (2005) J Appl Polym Sci 98:731

    CAS  Google Scholar 

  8. Chivukula P, Dusek K, Wang D, Duskova-Smrckova M, Kopeckova P, Kopecek J (2006) Biomaterials 27:1140

    CAS  PubMed  Google Scholar 

  9. Baghaei B, Jafari SH, Khonakdar HA, Wagenknecht U, Heinrich G (2014) J Appl Polym Sci 131:40625

    Google Scholar 

  10. Akhlaq M, Maryam F, Elaissari A, Ullah H, Adeel M, Hussain A, Ramzan M, Ullah O, Zeeshan Danish M, Iftikhar S, Aziz N (2018) Drug Deliv 25:916

    CAS  PubMed  PubMed Central  Google Scholar 

  11. Ghanaatian E, Entezam M (2019) J Appl Polym Sci 136:47843

    Google Scholar 

  12. Hosseini F, Entezam M, Jafari SH, Khonakdar HA, Abdouss M (2019) Polymer 58:732

    CAS  Google Scholar 

  13. Entezam M, Sedeh NN, Seyed HJ, Khonakdar HA (2019) J Appl Polym Sci 136

  14. Billard A, Pourchet L, Malaise S, Alcouffe P, Montembault A, Ladaviere C (2015) Carbohydr Polym 115:651

    CAS  PubMed  Google Scholar 

  15. Cao D, Zhang X, Akabar MD, Luo Y, Wu H, Ke X, Ci T (2019) Artif Cells Nanomed Biotechnol 47:181

    CAS  PubMed  Google Scholar 

  16. Ciobanu BC, Cadinoiu AN, Popa M, Desbrieres J, Peptu CA (2014) Mater Sci Eng C 43:383

    CAS  Google Scholar 

  17. Sercombe L, Veerati T, Moheimani F, Wu SY, Sood AK, Hua S (2015) Front Pharmacol 6:286

    PubMed  PubMed Central  Google Scholar 

  18. Tang JSJ, Smaczniak AD, Tepper L, Rosencrantz S, Aleksanyan M, Dahne L, Rosencrantz RR (2022) Macromol Biosci 22:e2100461

    PubMed  Google Scholar 

  19. Yadav D, Sandeep K, Pandey D, Dutta RK (2017) J Biotechnol Biomater 7:276

    Google Scholar 

  20. Danaei M, Dehghankhold M, Ataei S, Hasanzadeh Davarani F, Javanmard R, Dokhani A, Khorasani S, Mozafari MR (2018) Pharmaceutics 10:57

    PubMed  PubMed Central  Google Scholar 

  21. Baghaei B, Jafari SH, Khonakdar HA, Saeb MR, Wagenknecht U, Heinrich G (2015) Biomaterials 64(12):641–652

    CAS  Google Scholar 

  22. Ibaraki H, Kanazawa T, Oogi C, Takashima Y, Seta Y (2019) J Drug Deliv Sci Technol 50:155

    CAS  Google Scholar 

  23. Haghiralsadat F, Amoabediny G, Sheikhha MH, Zandieh-Doulabi B, Naderinezhad S, Helder MN, Forouzanfar T (2017) Chem Biol Drug Des 90:368

    CAS  PubMed  Google Scholar 

  24. Shi N-Q, Qi X-R (2021) Liposome-Based Drug Deliv Syst 37

  25. Gouda A, Sakr OS, Nasr M, Sammour O (2021) J Drug Deliv Sci Technol 61:102174

    CAS  Google Scholar 

  26. Schubert R (2003) Methods Enzymol 367:46

    CAS  PubMed  Google Scholar 

  27. Ajeeshkumar KK, Aneesh PA, Raju N, Suseela M, Ravishankar CN, Benjakul S (2021) Compr Rev Food Sci Food Saf 20:1280

    CAS  PubMed  Google Scholar 

  28. Ahsanizadeh S, Li L (2015) Biomed Eng Online 14:29

    PubMed  PubMed Central  Google Scholar 

  29. Firoozi M, Entezam M, Masaeli E, Ejeian F, Nasr-Esfahani MH (2021) J Appl Polym Sci 139:51485

    Google Scholar 

  30. Sonker AK, Rathore K, Teotia AK, Kumar A, Verma V (2019) J Appl Polym Sci 136:47393

    Google Scholar 

  31. Nafo W, Al-Mayah A (2020) PLoS ONE 15:e0233021

    CAS  PubMed  PubMed Central  Google Scholar 

  32. Chen S, Wang H, Jian Z, Fei G, Qian W, Luo G, Wang Z, Xia H (2020) Macromol Biosci 20:e1900385

    PubMed  Google Scholar 

  33. Nemati-Mahand S, Jahanmardi R, Kruppke B, Khonakdar HA (2023) J Biomed Mater Res. 1–10

  34. Shefa AA, Sultana T, Park MK, Lee SY, Gwon J-G, Lee B-T (2020) Mater Des 186:108313

    CAS  Google Scholar 

  35. Ren T, Gan J, Zhou L, Chen H (2020) Polymers 12:1729

    CAS  PubMed  PubMed Central  Google Scholar 

  36. Inamura I, Toki K, Tamae T, Araki T (1984) Polym J 16:657

    CAS  Google Scholar 

  37. Sakellariou P, Hassan A, Rowe R (1994) Colloid Polym Sci 272:220

    CAS  Google Scholar 

  38. Hsu C, Prausnitz J (1974) Macromolecules 7:320

    CAS  Google Scholar 

  39. Inamura I (1986) Polym J 18:269

    CAS  Google Scholar 

  40. Zhao C, Lu X, Hu Q, Liu S, Guan S (2017) Chem Res Chin Univ 33:995

    CAS  Google Scholar 

  41. Entezam M, Daneshian H, Nasirizadeh N, Khonakdar HA, Jafari SH (2017) Macromol Mater Eng 302:1600397

    Google Scholar 

  42. Himly N, Darwis D, Hardiningsih L (1993) Radiat Phys Chem 42:911

    Google Scholar 

  43. Zhou X, Hou C, Chang TL, Zhang Q, Liang JF (2020) Colloids Surf B 187:110645

    CAS  Google Scholar 

  44. Huang X, Brazel CS (2010) Chem Eng Commun 190:519

    Google Scholar 

  45. Hezaveh H, Muhamad II (2013) Chem Eng Res Des 91:508

    CAS  Google Scholar 

  46. Das S, Subuddhi U (2019) J Pharm Anal 9:108

    PubMed  Google Scholar 

  47. Alemi A, Zavar Reza J, Haghiralsadat F, Zarei Jaliani H, Haghi Karamallah M, Hosseini SA, Haghi Karamallah S (2018) J Nanobiotechnol 16:28

    Google Scholar 

  48. Suri A, Campos R, Rackus DG, Spiller NJ, Richardson C, Pålsson L-O, Kataky R (2011) Soft Matter 7:7071

    CAS  Google Scholar 

  49. Chen W, Palazzo A, Hennink WE, Kok RJ (2017) Mol Pharm 14:459

    CAS  PubMed  Google Scholar 

  50. Kim Y, Park E, Kim T, Na D (2021) s Note: MDPI stays neutral with regard to jurisdictional claims in published

  51. Chanda H, Das P, Chakraborty R, Ghosh A (2011) J Pharm Biomed Sci 5:1

    Google Scholar 

  52. Hamishehkar H, Emami J, Najafabadi AR, Gilani K, Minaiyan M, Mahdavi H, Nokhodchi A (2009) Colloids Surf B 74:340

    CAS  Google Scholar 

  53. Daneshian H, Entezam M, Nasisrizadeh N (2021) Iran J Polym Sci Technol 34:71

    Google Scholar 

  54. Khan S, Anwar N (2021) Carbohydr Polym 257:117617

    CAS  PubMed  Google Scholar 

  55. Alven S, Nqoro X, Aderibigbe BA (2020) Polymers 12:2286

    CAS  PubMed  PubMed Central  Google Scholar 

  56. Prakash J, Venkataprasanna K, Bharath G, Banat F, Niranjan R, Venkatasubbu GD (2021) Colloids Surf A 627:127166

    CAS  Google Scholar 

  57. Diomede F, Fonticoli L, Guarnieri S, Della Rocca Y, Rajan TS, Fontana A, Trubiani O, Marconi GD, Pizzicannella J (2021) Int J Mol Sci 22:7534

    CAS  PubMed  PubMed Central  Google Scholar 

  58. Ghosal K, Chatterjee S, Thomas S, Roy P (2022) AAPS PharmSciTech 24

  59. Arzani G, Haeri A, Daeihamed M, Bakhtiari-Kaboutaraki H, Dadashzadeh S (2015) Int J Nanomed 10:4797

    CAS  Google Scholar 

  60. Mokhtar M, Sammour OA, Hammad MA, Megrab NA (2008) Int J Pharm 361:104

    CAS  PubMed  Google Scholar 

  61. Briuglia ML, Rotella C, McFarlane A, Lamprou DA (2015) Drug Deliv Transl Res 5:231

    CAS  PubMed  Google Scholar 

  62. Mehanna MM, El-Kader NA, Samaha MW (2017) Braz J Pharm Sci 53

  63. Katragadda AK, Singh M, Betageri GV (1999) Drug Deliv 6:31

    CAS  Google Scholar 

  64. Lin C-C, Metters AT (2006) Adv Drug Deliv Rev 58:1379

    CAS  PubMed  Google Scholar 

  65. Ghosal K, Chandra A, Rajabalaya R, Chakraborty S, Nanda A (2012) Pharmazie 67:147

    CAS  PubMed  Google Scholar 

  66. Barman M, Mahmood S, Augustine R, Hasan A, Thomas S, Ghosal K (2020) Int J Biol Macromol 162:1849

    CAS  PubMed  Google Scholar 

  67. Roy B, Guha P, Bhattarai R, Nahak P, Karmakar G, Chettri P, Panda AK (2016) J Oleo Sci 65:399

    CAS  PubMed  Google Scholar 

  68. Siepmann J, Peppas NA (2001) Adv Drug Deliv Rev 48:139

    CAS  PubMed  Google Scholar 

  69. Jahanizadeh S, Yazdian F, Marjani A, Omidi M, Rashedi H (2017) Int J Biol Macromol 105:757

    CAS  PubMed  Google Scholar 

  70. Yallapu MM, Jaggi M, Chauhan SC (2010) Colloids Surf B 79:113

    CAS  Google Scholar 

  71. Alemi A, Reza JZ, Haghiralsadat F, Jaliani HZ, Karamallah MH, Hosseini SA, Karamallah SH (2018) J Nanobiotechnol 16:1

    Google Scholar 

  72. Ghafari M, Haghiralsadat F, Khanamani Falahati-Pour S, Zavar Reza J (2020) J Cell Biochem 121:3584

    CAS  PubMed  Google Scholar 

  73. Kharazmi A, Faraji N, Hussin RM, Saion E, Yunus WMM, Behzad K (2015) Beilstein J Nanotechnol 6:529

    CAS  PubMed  PubMed Central  Google Scholar 

  74. Lin B, Zhou S (2017) Prog Org Coat 106:145

    CAS  Google Scholar 

  75. Jo Y-Y, Lee K-G, Bragg JC, Lin C-C, Kweon H (2016) Int J Ind Entomol 32:35

    Google Scholar 

  76. Guan Y, Qi X-M, Zhang B, Chen G-G, Peng F, Sun R-C (2015) BioResources 10:1378

    Google Scholar 

  77. Kaewnopparat N, Kaewnopparat S, Jangwang A, Maneenaun D, Chuchome T, Panichayupakaranant P (2009) World Acad Sci Eng Technol 55:229

    Google Scholar 

  78. Wan W, Bannerman AD, Yang L, Mak H (2014) Polym Cryogels 283

  79. Ghobril C, Grinstaff M (2015) Chem Soc Rev 44:1820

    CAS  PubMed  Google Scholar 

  80. Xue H, Hu L, Xiong Y, Zhu X, Wei C, Cao F, Zhou W, Sun Y, Endo Y, Liu M (2019) Carbohydr Polym 226:115302

    CAS  PubMed  Google Scholar 

  81. Lan G, Zhu S, Chen D, Zhang H, Zou L, Zeng Y (2021) Front Bioeng Biotechnol 9:1277

    Google Scholar 

  82. Khan MUA, Razaq SIA, Mehboob H, Rehman S, Al-Arjan WS, Amin R (2021) Polymers 13:3703

    CAS  PubMed  PubMed Central  Google Scholar 

  83. Agarwal R, Alam MS, Gupta B (2013) J Biomater Tissue Eng 3:273

    CAS  Google Scholar 

  84. Bavarsad N, Kouchak M, Mohamadipour P, Sadeghi-Nejad B (2016) J Adv Pharm Technol Res 7:91

    CAS  PubMed  PubMed Central  Google Scholar 

  85. Wu W, Dai Y, Liu H, Cheng R, Ni Q, Ye T, Cui W (2018) Drug Deliv 25:1642

    CAS  PubMed  PubMed Central  Google Scholar 

  86. Saidi M, Dabbaghi A, Rahmani S (2020) Polym Bull 77:3989

    CAS  Google Scholar 

  87. Jøraholmen MW, Basnet P, Tostrup MJ, Moueffaq S, Škalko-Basnet N (2019) Pharmaceutics 11:53

    PubMed  PubMed Central  Google Scholar 

  88. Mahkam M, Doostie L, Siadat SO (2006) Inflammopharmacology 14:72

    CAS  PubMed  Google Scholar 

Download references

Funding

The authors have not disclosed any funding.

Author information

Authors and Affiliations

  1. Department of Chemical and Polymer Engineering, Yazd University, Yazd, Iran

    Atefeh Jafari Jezeh & Mehdi Entezam

  2. Department of Advanced Medical Sciences and Technologies, School of Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Bibi Fatemeh Haghiralsadat & Habib Nikukar

  3. Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Sadoughi University of Medical Sciences, Yazd, Iran

    Fatemeh Sadeghian-Nodoushan

  4. Medical Nanotechnology and Tissue Engineering Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, 8916877391, Iran

    Bibi Fatemeh Haghiralsadat, Habib Nikukar & Fatemeh Sadeghian-Nodoushan

  5. Department of Polymer Processing, Iran Polymer and Petrochemical Institute, Tehran, Iran

    Hossein Ali Khonakdar

Authors
  1. Atefeh Jafari Jezeh
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mehdi Entezam
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Bibi Fatemeh Haghiralsadat
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Habib Nikukar
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Fatemeh Sadeghian-Nodoushan
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Hossein Ali Khonakdar
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mehdi Entezam.

Ethics declarations

Competing interest

The authors declare no competing interests.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Jafari Jezeh, A., Entezam, M., Haghiralsadat, B.F. et al. Liposomal Nanocarriers-Loaded Poly(vinyl alcohol) (PVA)/Poly(ethylene glycol) (PEG) Hydrogels: Physico-mechanical Properties and Drug Release. J Polym Environ 31, 5110–5125 (2023). https://doi.org/10.1007/s10924-023-02932-9

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10924-023-02932-9

Keywords

Search

Navigation