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Synthesis and Characterization of a Novel pH-Sensitive Aluminum Crosslinked Carboxymethyl Tragacanth Beads for Extended and Enteric Drug Delivery

Abstract

Carboxymethyl tragacanth (CM-TG) with a DS of 1.2 was synthesized and characterized for drug delivery using diclofenac sodium as a model drug. The mixture of CM-TG and drug was ionically crosslinked using aluminum chloride to form drug-loaded beads. The concentrations of 10 and 20% w/w solution of CM-TG were found to produce beads with acceptable qualities. The beads exhibited pH-dependent swelling. The highest swelling was observed at pH 6.8 which evidences the possibility to release the drug in the colon. FT-IR and TGA confirmed carboxymethylation of tragacanth and the absence of drug-polymer interaction. The diclofenac sodium entrapment efficiency was 30–35% while the loading varies from 4.5 to 18% w/w based upon the drug-polymer ratio. The beads could extend the drug release up to 180 min at pH 6.8. The pH-responsive CM-TG hydrogel beads are biocompatible and could be exploited as a new excipient in developing enteric release formulations.

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References

  1. Lapasin R (2012) Rheology of industrial polysaccharides: theory and applications. Springer Science & Business Media, New York

    Google Scholar 

  2. Roshchina VV, Roshchina VD (2012) The excretory function of higher plants. Springer Science & Business Media, New York

    Google Scholar 

  3. Mirhosseini H, Amid BT (2012) Food Res Int 461:387

    Article  CAS  Google Scholar 

  4. Şen M, Hayrabolulu H, Taşkın P, Torun M, Demeter M, Cutrubinis M, Güven O (2016) Radiat Phys Chem 124:225

    Article  CAS  Google Scholar 

  5. Rana V, Rai P, Tiwary AK, Singh RS, Kennedy JF, Knill CJ (2011) Carbohyd Polym 833:1031

    Article  CAS  Google Scholar 

  6. Gupta S, Sharma P, Soni P (2004) J Appl Polym Sci 944:1606

    Article  CAS  Google Scholar 

  7. Kaity S, Isaac J, Ghosh A (2013) Carbohyd Polym 941:456

    Article  CAS  Google Scholar 

  8. Gupta AP, Verma DK (2015) J Nanostruct Chem 54:405

    Article  CAS  Google Scholar 

  9. Rajput G, Pandey I, Joshi G (2015) Carbohyd Polym 117:494

    Article  CAS  Google Scholar 

  10. Srivastava A, Gowda DV, Hani U, Shinde CG, Osmani RAM (2015) RSC Adv 555:44652

    Article  CAS  Google Scholar 

  11. Pandey PK, Banerjee J, Taunk K, Behari K (2003) J Appl Polym Sci 895:1341

    Article  CAS  Google Scholar 

  12. Pandey PK, Srivastava A, Tripathy J, Behari K (2006) Carbohyd Polym 654:414

    Article  CAS  Google Scholar 

  13. Pandey S, Mishra SB (2011) Int J Biol Macromol 494:527

    Article  CAS  Google Scholar 

  14. Behari K, Kumar R, Tripathi M, Pandey PK (2001) Macromol Chem Phys 2029:1873

    Article  Google Scholar 

  15. Mundargi RC, Agnihotri SA, Patil SA, Aminabhavi TM (2006) J Appl Polym Sci 1011:618

    Article  CAS  Google Scholar 

  16. Gupta S, Sharma P, Soni P (2005) Carbohyd Polym 594:501

    Article  CAS  Google Scholar 

  17. Rajput G, Pandey I, Joshi G, Bisht SS (2015) J Indian Acad Wood Sci 121:1

    Article  Google Scholar 

  18. Baveja S, Rao KR, Devi KP (1987) Int J Pharm 391:39

    Article  Google Scholar 

  19. Gralen N, Kärrholm M (1950) J Colloid Sci 51:21

    Article  Google Scholar 

  20. Pushpamalar V, Langford SJ, Ahmad M, Hashim K, Lim YY (2013) J Appl Polym Sci 1281:451

    Article  CAS  Google Scholar 

  21. Veeramachineni AK, Sathasivam T, Muniyandy S, Janarthanan P, Langford SJ, Yan LY (2016) Appl Sci 66:170

    Article  CAS  Google Scholar 

  22. Bao D, Chen M, Wang H, Wang J, Liu C, Sun R (2014) Carbohyd Polym 110:113

    Article  CAS  Google Scholar 

  23. Boppana R, Kulkarni RV, Setty CM, Kalyane NV (2010) Acta Pharmaceutica Sciencia 52:137

    CAS  Google Scholar 

  24. Khalil HA, Ismail H, Rozman H, Ahmad M (2001) Eur Polymer J 375:1037

    Article  Google Scholar 

  25. Kačuráková M, Belton PS, Wilson RH, Hirsch J, Ebringerová A (1998) J Sci Food Agric 771:38

    Article  Google Scholar 

  26. Peng HH, Chen J, Jiang DY, Li M, Feng L, Losic D, Dong F, Zhang YX (2016) J Colloid Interface Sci 484:1

    Article  CAS  PubMed  Google Scholar 

  27. Sun R, Tomkinson J, Wang Y, Xiao B (2000) Polymer 417:2647

    Article  Google Scholar 

  28. Kaith BS, Jindal R, Kapur G (2013) Iran Polym J 228:561

    Google Scholar 

  29. Biswal D, Singh R (2004) Carbohyd Polym 574:379

    Article  CAS  Google Scholar 

  30. Pushpamalar V, Langford SJ, Ahmad M, Lim YY (2006) Carbohyd Polym 642:312

    Article  CAS  Google Scholar 

  31. Haxaire K, Marechal Y, Milas M, Rinaudo M (2003) Biopolymers 723:149

    Article  CAS  Google Scholar 

  32. Kawadkar J, Meenakshi KC, Ram A (2010) DARU J Pharm Sci 183:211

    Google Scholar 

  33. Viseras M-T, Aguzzi C, Cerezo P, Cultrone G, Viseras C (2009) J Microencapsul 263:279

    Article  CAS  Google Scholar 

  34. Agnihotri SM, Vavia PR (2009) Nanomedicine 51:90

    Article  CAS  Google Scholar 

  35. Shalviri A, Liu Q, Abdekhodaie MJ, Wu XY (2010) Carbohyd Polym 794:898

    Article  CAS  Google Scholar 

  36. Bukhari SMH, Khan S, Rehanullah M, Ranjha NM (2015) Int J Polym Sci 2015:15

    Article  CAS  Google Scholar 

  37. Sullad AG, Manjeshwar LS, Aminabhavi TM (2010) Ind Eng Chem Res 4916:7323

    Article  CAS  Google Scholar 

  38. Goyal P, Kumar V, Sharma P (2007) Carbohyd Polym 692:251

    Article  CAS  Google Scholar 

  39. Ahuja M, Singh S, Kumar A (2013) Int J Biol Macromol 53:114

    Article  CAS  PubMed  Google Scholar 

  40. Piyakulawat P, Praphairaksit N, Chantarasiri N, Muangsin N (2007) AAPS PharmSciTech 84:120

    Article  Google Scholar 

  41. Kashyap M, Archana D, Semwal A, Dutta J, Dutta PK (2016) Chitosan: a promising substrate for regenerative medicine in drug formulation, in chitin and chitosan for regenerative medicine. Springer, New York p, p 261

    Book  Google Scholar 

  42. Tavano L, Pinazo A, Abo-Riya M, Infante MR, Manresa MA, Muzzalupo R, Pérez L (2014) Colloids Surf B 120:160

    Article  CAS  Google Scholar 

  43. Hosny EA, Al-Helw AA-RM (1998) Pharm Acta Helv 725:255

    Article  Google Scholar 

  44. Huang X, Brazel CS (2001) J Control Release 732:121

    Article  Google Scholar 

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Acknowledgements

The authors are thankful to the School of Science, Monash University Malaysia for providing the higher degree research financial assistance to the Ph.D. students.

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Correspondence to Janarthanan Pushpamalar.

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Veeramachineni, A.K., Sathasivam, T., Paramasivam, R. et al. Synthesis and Characterization of a Novel pH-Sensitive Aluminum Crosslinked Carboxymethyl Tragacanth Beads for Extended and Enteric Drug Delivery. J Polym Environ 27, 1516–1528 (2019). https://doi.org/10.1007/s10924-019-01448-5

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  • DOI: https://doi.org/10.1007/s10924-019-01448-5

Keywords

  • Biocompatible polymers
  • Carboxymethyl tragacanth gum
  • Drug delivery system
  • pH-responsive