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Physicochemical, Antimicrobial and Cytotoxic Characteristics of Corn Starch Film Containing Propolis for Wound Dressing

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Abstract

Modern dressings increase the rate of wound healing rather than just covering them. Dressing can protect the injured skin and keep it appropriately moist to speed up the healing process. In this study, the ethanolic extract of propolis loaded with corn starch was successfully prepared using solvent casting. Characterizations of the samples performed in respect to their mechanical properties were examined by scanning electron microscopy, contact angle, and attenuated total reflectance—fourier transform infrared spectroscopy, as well as antimicrobial capacities. The MTT assay using fibroblast cells showed the cell viability of corn starch in the ethanolic extract of propolis wound dressing. The results showed that by increasing the amount of ethanolic propolis extract from 0.25 to 1%, the tensile strength and the Young’s modulus of the samples were decreased, the elongation at the break increased about 15% as compared to the control films, and the contact angle properties were detected by a slightly hydrophobic character of the films in the antibacterial activity against Escherichia coli and Staphylococcus aureus even at low ethanolic extract of propolis concentrations (1%), mainly due to its phenolic compounds. Therefore, ethanolic extract of propolis loaded with corn starch film will be a potential candidate for wound dressing and skin tissue engineering.

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References

  1. Su C-H et al (1997) Biomaterials 18:17

    Article  Google Scholar 

  2. Wittaya-areekul S, Prahsarn C (2006) Int J Pharm 313:1

    Article  CAS  Google Scholar 

  3. Kannon GA, Garrett AB (1995) Dermatol Surg 21:7

    Google Scholar 

  4. Lin S-Y et al (2001) Biomaterials 22:22

    Google Scholar 

  5. Kavoosi G et al (2013) J Food Sci 78:2

    Google Scholar 

  6. Torres FG et al (2013) Starch-Stärke 65:7–8

    Article  CAS  Google Scholar 

  7. Gruen RL et al (1996) Aust N Z J Surg 66:3

    Article  Google Scholar 

  8. Persin Z et al (2011) Carbohyd Polym 84:1

    Article  CAS  Google Scholar 

  9. Castro JV et al (2005) Biomacromol 6:4

    Google Scholar 

  10. Donald AM (1994) Rep Prog Phys 57:11

    Article  Google Scholar 

  11. Arockianathan PM et al (2012) Int J Biol Macromol 50:4

    Google Scholar 

  12. Burdock G (1998) Food Chem Toxicol 36:4

    Article  Google Scholar 

  13. Juliano C et al (2007) J Drug Deliv Sci Technol 17:3

    Article  Google Scholar 

  14. Koo H et al (2000) Arch Oral Biol 45:2

    Article  Google Scholar 

  15. Alencar SM et al (2009) Quím Nova 32:1523–1527

    Google Scholar 

  16. Tosi B et al (1996) Phytother Res 10:4

    Article  Google Scholar 

  17. Scazzocchio F et al (2006) Microbiol Res 161:4

    Article  CAS  Google Scholar 

  18. Soylu E et al (2008) Asian J Chem 20:6

    Google Scholar 

  19. Kalogeropoulos N et al (2009) Food Chem 116:2

    Article  CAS  Google Scholar 

  20. Salehi H et al (2017) J Res Med Sci 22:110

    Article  PubMed  PubMed Central  Google Scholar 

  21. Peng Y et al (2013) Int J Biol Macromol 59:52

    Article  CAS  Google Scholar 

  22. Hambleton A et al (2008) Biomacromolecules 9(3):1058–1063

    Article  CAS  Google Scholar 

  23. Bitencourt C et al (2014) Food Hydrocoll 40:145–152

    Article  CAS  Google Scholar 

  24. Araújo GKP et al (2015) Int J Food Sci Technol 50:9

    Article  CAS  Google Scholar 

  25. Pastor C et al (2010) Carbohydr Polym 82:4

    Article  CAS  Google Scholar 

  26. Bodini R et al (2013) LWT-Food Sci Technol 51:1

    Article  CAS  Google Scholar 

  27. Chang-Bravo L et al (2014) React Funct Polym 85:11–19

    Article  CAS  Google Scholar 

  28. Abolghasemi Fakhri L et al (2013) Iran Food Sci Technol Res J 8:4

    Google Scholar 

  29. Braunwarth H et al (2014) Wound Med 5:16–20

    Article  Google Scholar 

  30. Xu Y et al (2005) Ind Crops Prod 21:2

    Google Scholar 

  31. Pereira VA et al (2015) Food Hydrocoll 43:180–188

    Article  CAS  Google Scholar 

  32. Mano J et al (2003) J Mater Sci: Mater Med 14:2

    Google Scholar 

  33. Seligra PG et al (2016) Carbohydr Polym 138:66–74

    Article  CAS  Google Scholar 

  34. Córdoba AL et al (2013) Carbohydr Polym 95:1

    Article  CAS  Google Scholar 

  35. Mathew S et al (2006) Biopolymers 82:2

    Article  CAS  Google Scholar 

  36. Jaiswal R et al (2010) J Agric Food Chem 58:9

    Google Scholar 

  37. Bodini RB et al (2013) LWT-Food Sci Technol 51:104–110

    Article  CAS  Google Scholar 

  38. Sharaf S et al (2013) Int J Biol Macromol 59:408–416

    Article  CAS  Google Scholar 

  39. Popova M et al (2005) Phytomedicine 12:3

    Article  CAS  Google Scholar 

  40. Yaghoubi M et al (2007) DARU J Pharm Sci 15:1

    Google Scholar 

  41. Mishima S et al (2005) Bioorg Med Chem 13:20

    Article  CAS  Google Scholar 

  42. Mahdieh Z et al (2016) Mater Sci Eng C 69:301–310

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Biomaterials, Tissue Engineering and Nanotechnology, School of Advanced Medical Technologies, Isfahan University of Medical Sciences, Isfahan, Iran

    Asghar Eskandarinia & Maria Agheb

  2. Biosensor Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

    Mohammad Rafienia

  3. Department of microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

    Sepehr Navid

Authors
  1. Asghar Eskandarinia
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  2. Mohammad Rafienia
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  3. Sepehr Navid
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  4. Maria Agheb
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Correspondence to Mohammad Rafienia.

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Eskandarinia, A., Rafienia, M., Navid, S. et al. Physicochemical, Antimicrobial and Cytotoxic Characteristics of Corn Starch Film Containing Propolis for Wound Dressing. J Polym Environ 26, 3345–3351 (2018). https://doi.org/10.1007/s10924-018-1216-5

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  • DOI: https://doi.org/10.1007/s10924-018-1216-5

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