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Poly(Lactic Acid)-co-Aspartic Acid Copolymers: Possible Utilization in Drug Delivery Systems

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Abstract

The synthesis and characterization of poly(lactic acid)-co-aspartic acid copolymers (PLA-co-Asp) were presented. Subsequently, the synthesized PLA-co-Asp copolymers were tested as biodegradable carriers in drug delivery systems. PLA-co-Asp copolymers were synthesized by solution polycondensation procedure, using different molar ratios PLA/l-aspartic acid (2.33/1, 1/1, 1/2.33), manganese acetate and phosphoric acid as catalysts and N,N′-dimethyl formamide (DMF)/toluene as solvent mixture. The copolymers were characterized by FT-IR and 1H-NMR spectroscopy, gel permeation chromatography (GPC), DSC and TG-DTG analyses. Diclofenac sodium, a non steroidal anti-inflammatory drug was subsequently loaded into PLA-co-Asp copolymers. The in vitro drug release experiments were done by dialysis of the copolymer/drug systems, in phosphate buffer solution (pH = 7.4, at 37 °C) and monitored by UV spectroscopy.

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Acknowledgments

The authors are grateful for the financial support from the Romanian National Authority for Scientific Research CNCS–UEFISCDI, project: Interdisciplinary research on multifunctional hybrid particles for bio-requirements “INTERBIORES” PN–II–PT–PCCA–2011–3.2–0428, Grant no. 211/2012, and project Binanomed: Antimicrobial bionanocomposites for medical applications, Grant PCCA/II, no. 164/2012, CNCCS–UEFISCDI.

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  1. “Petru Poni” Institute of Macromolecular Chemistry, 41A Gr. Ghica Voda Alley, 700487, Iasi, Romania

    Nita Tudorachi, Rodica Lipsa, Cornelia Vasile & Fanica Mustata

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  1. Nita Tudorachi
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  2. Rodica Lipsa
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  3. Cornelia Vasile
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  4. Fanica Mustata
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Correspondence to Nita Tudorachi.

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Tudorachi, N., Lipsa, R., Vasile, C. et al. Poly(Lactic Acid)-co-Aspartic Acid Copolymers: Possible Utilization in Drug Delivery Systems. J Polym Environ 21, 1064–1071 (2013). https://doi.org/10.1007/s10924-013-0587-x

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