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Biodegradable Chitosan-g-Poly(methacrylamide) Microspheres for Controlled Release of Hypertensive Drug

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Abstract

Chitosan-g-poly(methacrylamide) (CS-g-PMAAm) was synthesized by redox polymerization. The synthesized graft copolymers were used to prepare microspheres (MS) by water/oil (W/O) emulsion technique and cross-linked with glutaraldehyde (GA). Developed microspheres were encapsulated using enalapril maleate (ENAM) as a model drug (hypertension) and characterized by fourier transform infrared spectroscopy, differential scanning calorimetry and scanning electron microscopy. The physico-chemical properties of the microspheres were studied by calculating drug entrapment efficiency, and drug release kinetics. % of encapsulation efficiency (% EE) increased with increase in drug loading and methacrylamide (MAAm) content. The minimum % EE (65.2 ± 1.6) was observed in case of microsphere containing 40 % MAAm, 5 % ENAM and 10 mL glutaraldehyde. The release profiles indicate that formulation containing highest (10 mL) crosslinking agent microspheres has the slow release.

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References

  1. Garcia MO, Blanco D, Martin JA, Teijon JM (2000) Euro Polym J 36:111–122

    Article  CAS  Google Scholar 

  2. Ravindra S, Vara Prasad K, Narayana Reddy N, Vimala K, Mohana Raju K (2011) J Polym Environ 192:413–418

    Article  Google Scholar 

  3. Vara Prasad K, Vimala K, Ravindra S, Narayana Reddy N, Siva Mohan Reddy G, Mohan Raju K (2012) J Polym Environ 202:573–582

    Article  Google Scholar 

  4. Mundargi RC, Srirangarajan S, Agnihotri SA, Patil SA, Setty SB, Aminabhavi TM (2007) J Control Rel 119:59–68

    Article  CAS  Google Scholar 

  5. Lakshmi Narayana Reddy C, Yerri Swamy B, Venkata Prasad C, Subha MCS, Chowdoji Rao K (2010) J Appl Polym Sci 118:2342–2349

    Google Scholar 

  6. Soppimath KS, Kulkarni AR, Aminabhavi TM (2001) J Control Rel 75:331–345

    Article  CAS  Google Scholar 

  7. Yerriswamy B, Lakshminarayana Reddy C, Venkata Prasad C, Subha MCS, Chowdojirao K (2011) Design monomers polym 14:25–37

    Article  CAS  Google Scholar 

  8. Checa-Casalengua P, Jiang C, Bravo-Osuna I, Tucker BA, Molina-Martínez IT, Young MJ, Herrero-Vanrell RJ (2011) J Control Rel 156:92–100

    Article  CAS  Google Scholar 

  9. Wang J, Chen JS, Zong JY, Zhao D, Li F, Zhuo RX, Cheng SX (2010) J Phys Chem C 114:18940–18945

    Article  CAS  Google Scholar 

  10. Prabaharan M, Grailer JJ, Douglas A, Steeber SG (2008) Macromol Biosci 8:843–851

    Article  CAS  Google Scholar 

  11. Kriwet BE, Walter E, Kissel T (1998) J Control Rel 56:149–158

    Article  CAS  Google Scholar 

  12. Venkata Prasad C, Yerri Swamy B, Lakshmi Narayana Reddy C, Vara Prasad K, Sudhakara P, Subha MCS, Jung IL Song, Chowdoji Rao K (2012) J Polym Environ 20:344–352

    Article  Google Scholar 

  13. Yerri Swamy B, Venkata Prasad C, Reddy CLN, Sudhakara P, Chung ID, Subha MCS, Chowdoji Rao K (2012) J Appl Polym Sci 125:555–561

    Article  Google Scholar 

  14. Hamdi J, Ponchel G, Dunchene D (1998) J Control Rel 55:193–200

    Article  CAS  Google Scholar 

  15. Najjar AMK, Yunus WMZW, Ahmad MB, Rahaman MZAB (2000) J Appl Polym Sci 77:2314–2318

    Article  CAS  Google Scholar 

  16. Singh DK, Ray AR (1994) J Appl Polym Sci 53:1115–1121

    Article  CAS  Google Scholar 

  17. Binder WH, Gruber H (2000) Macromole chem Phys 201:949–957

    Article  CAS  Google Scholar 

  18. Park K, Shalaby WSW, Park H (1993) Biodegradable hydrogels for drug delivery. Technomic, New York

    Google Scholar 

  19. Kang DW, Choi HR, Kweon DK (1999) J Appl Polym Sci 73:469–476

    Article  CAS  Google Scholar 

  20. Peniche C, Monal WA, Davidenkom N, Sastre R, Gallardo A, Roman JS (1999) Biomaterials 20:1869–1878

    Article  CAS  Google Scholar 

  21. Mi L, Tan YC, Liang HF, Sung HW (2002) Biomaterials 23:181–191

    Article  CAS  Google Scholar 

  22. Risbud MV, Hardikar AA, Bhat SV, Bhonde RR (2000) J Control Rel 68:23–30

    Article  CAS  Google Scholar 

  23. Thomas C, Sharma P (1990) Biomat Artif Cells Artif Organs 18:1–24

    Google Scholar 

  24. Illuum L (1998) Pharm Res 15:1326–1331

    Article  Google Scholar 

  25. Nakatsuka S, Andrady AL (1992) J Appl Polym Sci 44:17–28

    Article  CAS  Google Scholar 

  26. Thacharodi D, Rao KP (1993) J Chem Tech Biotech 58:177–181

    Article  CAS  Google Scholar 

  27. Moncloa F, Sromovsky JA, Walker JF, Davies RO (1985) Drugs 30:82–89

    Article  Google Scholar 

  28. Warner NJ, Rush JE (1983) Safety profiles of the angiotensin-converting enzyme inhibitors. Drugs 35:89–97

    Article  Google Scholar 

  29. Bellamy LJ (1980) The infrared spectra of complex molecules. New York: Chapman & Hall. Chem Phy 201:949–957

  30. Aminabhavi TM, Naik HG (1998) J Haz mater 60:175–203

    Article  CAS  Google Scholar 

  31. Angadi SC, Manjeshwar LS, Aminabhavi TM (2011) Ind Eng Chem Res 50:4504–4514

    Article  CAS  Google Scholar 

  32. Krishna Rao KSV, Madhusudana Rao K, Nagendra Kumar PV, Chung I-D (2010) Iranian Polym J 19:265–276

    Google Scholar 

  33. Kumbar SG, Aminabhavi TM (2003) J Appl Polym Sci 89:2940–2949

    Article  CAS  Google Scholar 

  34. Kumbar SG, Soppimath KS, Aminabhavi TM (2003) J Appl Polym Sci 87:1525–1536

    Article  CAS  Google Scholar 

  35. Ramesh Babu V, Hosamani KM, Aminabhavi TM (2008) Carbohydr Polym 71:208–217

    Article  Google Scholar 

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Acknowledgments

This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (No. 2010-0008129).

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Authors and Affiliations

  1. Department of Polymer Science and Engineering, Pusan National University, Busan, 609-735, Korea

    Bala Yerri Swamy & Ildoo Chung

  2. Department of Mechanical Engineering, Changwon National University, Changwon, 641-773, Korea

    Chavidi Venkata Prasad

  3. Department of Polymer Science and Technology, S. K. University, Anantapur, 515 003, AP, India

    M. N. Prabhakar & Kashay Chowdoji Rao

  4. Department of Chemistry, S. K. University, Anantapur, 515 003, AP, India

    M. C. S. Subha

Authors
  1. Bala Yerri Swamy
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  2. Chavidi Venkata Prasad
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  3. M. N. Prabhakar
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  4. Kashay Chowdoji Rao
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  5. M. C. S. Subha
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  6. Ildoo Chung
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Correspondence to Ildoo Chung.

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Swamy, B.Y., Prasad, C.V., Prabhakar, M.N. et al. Biodegradable Chitosan-g-Poly(methacrylamide) Microspheres for Controlled Release of Hypertensive Drug. J Polym Environ 21, 1128–1134 (2013). https://doi.org/10.1007/s10924-012-0554-y

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  • DOI: https://doi.org/10.1007/s10924-012-0554-y

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