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Biodegradable Chitosan Hydrogels for In Vitro Drug Release Studies of 5-Flurouracil an Anticancer Drug

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Abstract

Novel semi-interpenetrating network (semi-IPN) hydrogels based on biodegradable chitosan and poly(N-isopropylacrylamide-co-2-acrylamido-2-methyl-1-propanesulfonic acid) were prepared by free radical addition polymerization. Fourier transform infrared spectra and scanning electron microscopy were used to characterize the semi-IPN hydrogels and the results showed that chitosan and poly(N-isopropylacrylamide-co-2-acrylamide-2-methyl-1-propanesulfonic acid) semi-IPN hydrogels were coupled by the interaction of the functional groups present in NIPAAm, CS and AMPS units. The PNIPAAm and P(NIPAAm-AMPS)/CS hydrogels have lower critical solution temperature and the same was confirmed with the help of differential scanning calorimetry as well as with the temperature dependent swelling curves. The model anti cancer drug, 5-fluorouracil (5-FU) was loaded into the semi-IPN hydrogels, at ambient temperature. The 5-FU loading capacity and release behaviour were investigated with these hydrogels acting as carriers for controlled release. The released 5-FU concentration was calculated with the help of UV spectrophotometer at 266.5 nm.

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Author notes

  1. Kokkarachedu Varaprasad

    Present address: Department of Pharmacy and Practice, Creighton University, Omaha, NE, USA

Authors and Affiliations

  1. Synthetic Polymer Laboratory, Department of Polymer Science and Technology, Sri Krishnadevaraya University, Anantapur, 515055, India

    Kokkarachedu Varaprasad, K. Vimala,  Sakey Ravindra, N. Narayana Reddy, G. Siva Mohana Reddy & K. Mohana Raju

  2. Department of Chemical Engineering Technology, University of Johannesburg, Doornfontein Campaus, Johannesburg, South Africa

    Sakey Ravindra

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  1. Kokkarachedu Varaprasad
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  2. K. Vimala
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  5. G. Siva Mohana Reddy
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  6. K. Mohana Raju
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Correspondence to Kokkarachedu Varaprasad.

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Kokkarachedu Varaprasad, Vimala, K., Sakey Ravindra et al. Biodegradable Chitosan Hydrogels for In Vitro Drug Release Studies of 5-Flurouracil an Anticancer Drug. J Polym Environ 20, 573–582 (2012). https://doi.org/10.1007/s10924-012-0412-y

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