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Formulation and Characterization of Sodium Alginate g-Hydroxy Ethylacrylate Bio-Degradable Polymeric Beads: In Vitro Release Studies

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Abstract

Novel type of highly swollen beads were prepared by grafting 2-hydroxyethylacrylate onto biodegradable Sodium alginate (SA) via free-radical polymerization using potassium persulphate as an initiator and Triprolidine hydrochloride as a model drug. Evidence of grafting was obtained by fourier transform infrared spectroscopic technique. Morphological properties of the beads were studied by SEM analysis. Thermal properties and crystallinity of the beads were characterized using differential scanning calorimetry and thermogravimetric analysis and X-ray diffraction techniques, respectively. Dissolution experiments were performed to study the release profiles at 37 °C in phosphate buffer solution (pH-7.4). Effect of monomer content, crosslinking agent and drug/polymer ratio on swelling properties and release profiles were also comparatively studied. A dissolution result concludes that drug release decreases with increasing crosslinker content. The highest release (96%) was obtained for the beads prepared with 0.5 mL crosslinking agent. Equilibrium swelling degree also supports the drug release profiles confirming SA-g-HEA beads showed better release profiles compare to plain SA beads.

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Acknowledgments

We immensely thank the UGC, New Delhi, India (UGC-RFSMS scheme), National Research foundation of Korea (NRF) grant funded by the Korea Government (MEST) (No:2011-0030804) and Brain Korea (BK21) Projects Corps of the second phase, Changwon National University, South Korea for providing financial assistance.

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Authors and Affiliations

  1. Department of Polymer Science and Technology, S.K.University, Anantapur, AP, 515003, India

    Chavidi Venkata Prasad & Kashay Chowdoji Rao

  2. Department of Chemistry, S.K.University, Anantapur, AP, 515003, India

    Bala Yerri Swamy, Chanda Lakshmi Narayana Reddy & MCS Subha

  3. Department of Mechanical Engineering, Changwon National University, Changwon, SouthKorea

    Chavidi Venkata Prasad, Posa Sudhakara & Song Jung Il

  4. Department of Polymer Science and Engineering, Pusan National University, Pusan, SouthKorea

    Bala Yerri Swamy

  5. Department of Pharmacy and Practice, Creighton University Schools of Pharmacy and Health Professions and Medicine, 2500 California Plaza, Omaha, NE, 68178, USA

    Kokkarachedu Vara Prasad

Authors
  1. Chavidi Venkata Prasad
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  2. Bala Yerri Swamy
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  3. Chanda Lakshmi Narayana Reddy
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  4. Kokkarachedu Vara Prasad
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  5. Posa Sudhakara
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  6. MCS Subha
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  7. Song Jung Il
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  8. Kashay Chowdoji Rao
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Corresponding authors

Correspondence to Song Jung Il or Kashay Chowdoji Rao.

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Venkata Prasad, C., Yerri Swamy, B., Lakshmi Narayana Reddy, C. et al. Formulation and Characterization of Sodium Alginate g-Hydroxy Ethylacrylate Bio-Degradable Polymeric Beads: In Vitro Release Studies. J Polym Environ 20, 344–352 (2012). https://doi.org/10.1007/s10924-011-0401-6

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  • DOI: https://doi.org/10.1007/s10924-011-0401-6

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