A Novel Microwave Sensor to Detect Specific Biomarkers in Human Cerebrospinal Fluid and Their Relationship to Cellular Ischemia During Thoracoabdominal Aortic Aneurysm Repair

  • M. Fok
  • M. Bashir
  • H. Fraser
  • N. Strouther
  • A. Mason
Non-invasive Diagnostic Systems
Part of the following topical collections:
  1. Patient Facing Systems

Abstract

Thoraco-abdominal aneurysms (TAAA) represents a particularly lethal vascular disease that without surgical repair carries a dismal prognosis. However, there is an inherent risk from surgical repair of spinal cord ischaemia that can result in paraplegia. One method of reducing this risk is cerebrospinal fluid (CSF) drainage. We believe that the CSF contains clinically significant biomarkers that can indicate impending spinal cord ischaemia. This work therefore presents a novel measurement method for proteins, namely albumin, as a precursor to further work in this area. The work uses an interdigitated electrode (IDE) sensor and shows that it is capable of detecting various concentrations of albumin (from 0 to 100 g/L) with a high degree of repeatability at 200 MHz (R2 = 0.991) and 4 GHz (R2 = 0.975).

Keywords

Thoraco-abdominal aneurysms Electromagnetic wave sensors Interdigitatedelectrode In-situ monitoring 

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • M. Fok
    • 1
    • 2
  • M. Bashir
    • 1
  • H. Fraser
    • 1
  • N. Strouther
    • 1
  • A. Mason
    • 1
  1. 1.Thoracic Aortic Aneurysm ServiceLiverpool Heart & Chest HospitalLiverpoolUK
  2. 2.Liverpool John Moores UniversityBuilt Environment and Sustainable Technologies (BEST) Research Institute, RF and Microwave Research GroupLiverpoolUK

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