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The Eleventh ENBDC Workshop: Advances in Technology Help to Unveil Mechanisms of Mammary Gland Development and Cancerogenesis

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Abstract

The eleventh annual workshop of the European Network for Breast Development and Cancer, Methods in mammary gland biology and breast cancer, took place on the 16th to 18th of May 2019 in Weggis, Switzerland. The main topics of the meeting were high resolution genomics and proteomics for the study of mammary gland development and cancer, breast cancer signaling, tumor microenvironment, preclinical models of breast cancer, and tissue morphogenesis. Exciting novel findings in, or highly relevant to, mammary gland biology and breast cancer field were presented, with insights into the methods used to obtain them. Among others, the discussed methods included single-cell RNA sequencing, genetic barcoding, lineage tracing, spatial transcriptomics, optogenetics, genetic mouse models and organoids.

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Abbreviations

53BP1:

p53-binding protein 1

BRCA1:

BRCA1 DNA repair associated

cAMP:

cyclic adenosine monophosphate

CAF:

cancer-associated fibroblast

CDC42EP3:

cell division cycle 42 effector protein 3

CREB1:

cAMP responsive element binding protein 1

EGFR:

epithelial growth factor receptor

ECM:

extracellular matrix

EMBL:

European Molecular Biology Laboratory

ENBDC:

European Network of Breast Development and Cancer

ER:

estrogen receptor

FGF:

fibroblast growth factor

FGFR:

fibroblast growth factor receptor

IDC:

invasive ductal carcinoma

MSPC:

mammary stem/progenitor cell

NOTCH4:

notch receptor 4

PARP:

poly (ADP-ribose) polymerase

PARPi:

PARP inhibitor

PR:

progesterone receptor

RSK2:

p90 ribosomal S6 kinase 2

scRNAseq:

single cell RNA sequencing

TNBC:

triple negative breast cancer

UK:

United Kingdom

VPS11:

vacuolar protein sorting-associated protein 11 homolog

YAP:

Yes-associated protein

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Acknowledgements

The authors thank Xiomara Banholzer for help with the organization of the meeting.

Funding

Funding for the meeting was received from Krebsforschung Schweiz and Krebsliga Schweiz, Novartis, The Company of Biologists, Frontiers in Cell and Developmental Biology, Cytoskeleton Inc., and from European Association for Cancer Research. VV has been supported by the Swiss National Science Foundation, EP has been supported by Academy of Finland and Finnish Cultural foundation. MLM received funding from Academy of Finland, Cancer Foundation Finland, and Sigrid Juselius Foundation. Research in the MB-A laboratory is supported by the Swiss Initiative for Systems Biology- SystemsX, the European Research Council (grant no. 694033 STEM-BCPC), the Swiss National Science Foundation, Novartis, the Krebsliga Beider Basel, the Swiss Cancer League, the Swiss Personalized Health Network (Swiss Personalized Oncology driver project) and the Department of Surgery of the University Hospital Basel. ZK is supported by the Grant Agency of Masaryk University (grants no. MUNI/G/1446/2018 and MUNI/E/0519/2019).

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Author notes

  1. Vida Vafaizadeh and Emilia Peuhu contributed equally to this work.

Authors and Affiliations

  1. Department of Biomedicine, University of Basel, Basel, Switzerland

    Vida Vafaizadeh

  2. Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland

    Emilia Peuhu

  3. Cancer Research Laboratory FICAN West, University of Turku and Turku University Hospital, Turku, Finland

    Emilia Peuhu

  4. Developmental Biology Program, Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland

    Marja L. Mikkola

  5. Department of Pharmacology, University of Cambridge, Cambridge, UK

    Walid T. Khaled

  6. Department of Biomedicine, Department of Surgery, University Hospital Basel, University of Basel, Basel, Switzerland

    Mohamed Bentires-Alj

  7. Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czech Republic

    Zuzana Koledova

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  1. Vida Vafaizadeh
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  2. Emilia Peuhu
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  3. Marja L. Mikkola
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Contributions

VV, EP, MLM, WTK, MB-A, and ZK wrote the manuscript. All authors approved the final manuscript.

Corresponding author

Correspondence to Zuzana Koledova.

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Vafaizadeh, V., Peuhu, E., Mikkola, M.L. et al. The Eleventh ENBDC Workshop: Advances in Technology Help to Unveil Mechanisms of Mammary Gland Development and Cancerogenesis. J Mammary Gland Biol Neoplasia 24, 201–206 (2019). https://doi.org/10.1007/s10911-019-09436-0

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