Advertisement

Journal of Mammary Gland Biology and Neoplasia

, Volume 14, Issue 3, pp 223–242 | Cite as

Contractile tissues in the mammary gland, with special reference to myoepithelium in the goat

  • K. C. Richardson
Article

The distribution of myoepithelium and smooth muscle in the lactating mammary gland of the goat has been examined by a new technique of silver impregnation which is applicable to sections up to 100μ in thickness. Myoepithelium covers the stromal surface of the epithelium of the alveoli, ducts and cisterns of the entire gland, and is thus much more abundant than is generally realized. Smooth muscle forms scattered inter-lobular bundles closely associated with the blood vessels. The theory that myoepithelial contraction is the principal factor concerned with 'let-down' and the ejection of milk is examined; other factors such as inter-lobular smooth muscle contraction, vascular changes, and elastic recoil of the stroma appear to play minor roles, if any, in this phenomenon. Hitherto, it has been assumed that myoepithelial cells are contractile because they bear structural resemblances to smooth muscle fibres. With the new technique structural changes have been found in the myoepithelium of contracted as compared with distended alveoli and ducts. These changes, together with the general orientation of myoepithelial cells, and the precise relationship between these cells and the folds in the secretory epithelium from contracted glands, are consistent with the assumption that myoepithelium is the contractile tissue in the mamma which responds to a neurohormonal mechanism involving oxytocin.

Keywords

Smooth Muscle Mammary Gland Oxytocin Myoepithelial Cell Smooth Muscle Contraction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Arnstein, C. 1895 Anat. Anz. 10, 410.Google Scholar
  2. Babkin, B. P. 1944 Secretory mechanism of the digestive glands, p. 676. New York: Hoeber.Google Scholar
  3. Benda, C. 1894 Derm. Z. 1, 94.CrossRefGoogle Scholar
  4. Bertkau, F. 1907 Anat. Anz. 30, 161.Google Scholar
  5. Biggs, R. 1947 J. Path. Bact. 59, 437.CrossRefGoogle Scholar
  6. Boeke, J. 1934 Z. mikr.-anat. Forsch. 35, 551.Google Scholar
  7. Buley, H. M. 1938 Arch. Derm. Syph., N.Y., 38, 340.Google Scholar
  8. Dempsey, E. W., Bunting, H. & Wislocki, G. B. 1947 Amer. J. Anat. 81, 309.PubMedCrossRefGoogle Scholar
  9. Ely, F. & Petersen, W. E. 1939 Amer. Soc. An. Prod. 32nd Ann. Meet. 80.Google Scholar
  10. Ely, F. & Petersen, W. E. 1941 J. Dairy Sci. 24, 211.CrossRefGoogle Scholar
  11. Folley, S. J. 1947 Brit. Med. Bull. 5, 142.Google Scholar
  12. Folley, S. J. & Greenbaum, A. L. 1947 Biochem. J. 41, 261.PubMedGoogle Scholar
  13. Gaines, W. L. 1915 Amer. J. Physiol. 38, 285.Google Scholar
  14. Hammond, J. 1936 Vet. Rec. 16, (N.S.), 519.Google Scholar
  15. Hoerr, N. L. 1936 Anat. Rec. 66, 149.CrossRefGoogle Scholar
  16. Kuzma, J. F. 1943 Amer. J. Path. 19, 473.PubMedGoogle Scholar
  17. Lenfers, P. 1907 Z. Fleisch- u. Milchhyg. 17, 340, 383, 424.Google Scholar
  18. McClung, C. E. 1937 Handbook of microscopical technique, 461. Oxford University Press.Google Scholar
  19. Petersen, W. E. 1942 Proc. Soc. exp. Biol., N.Y., 50, 298.Google Scholar
  20. Petersen, W. E. & Ludwick, T. M. 1942 Fed. Proc. 1, 66.Google Scholar
  21. Peyron, A. Corsy, F. & Surmont, J. 1926 Bull. Ass. franc. Cancer, 15, 21.Google Scholar
  22. Retterer, E. & Lelievre, A. 1911 J. Anat., Paris, 47, 8.Google Scholar
  23. Schäfer, E. A. 1915 Quart. J. exp. Physiol. 8, 379.Google Scholar
  24. Sheldon, W. H. 1941 Arch. Path Lab. Med. 31, 326.Google Scholar
  25. Sheldon, W. H. 1943 Arch. Path. Lab. Med. 35, 1.Google Scholar
  26. Swanson, E. W. & Turner, C. W. 1941 J. Dairy Sci. 24, 635.Google Scholar
  27. Takahara, K. 1934 Quoted from The physiology of human perspiration, Y. Kuno, 1934, p. 28. London: Churchill.Google Scholar
  28. Tgetgel, B. 1926 Schweiz. Arch. Tierheilk. 68, 335, 369.Google Scholar
  29. Turner, C. W. 1931 Res. Bull. Mo. agric. exp. Sta. No. 160.Google Scholar
  30. Turner, C. W. 1939 The comparative anatomy of the mammary glands (with special reference to the udder of cattle). Columbia, U.S.A.: University Missouri Co-op. Store.Google Scholar
  31. Turner, C. W. & Gomez, E. T. 1936 Res. Bull. Mlo. agric. exp. Sta. No. 240.Google Scholar
  32. Weber, A. 1944 Bull. Histol. Tech. micr. 21, 45.Google Scholar
  33. Yen, T. J. 1924 Quoted from The physiology of human perspiration, Y. Kuno, 1934, p. 27. London: Churchill.Google Scholar

Copyright information

© Royal Society (London) 2009

Authors and Affiliations

  • K. C. Richardson
    • 1
  1. 1.Department of AnatomyUniversity CollegeLondonUK

Personalised recommendations