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The Role of Endocrine Insulin-Like Growth Factor-I and Insulin in Breast Cancer

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Abstract

Epidemiologic studies demonstrate that breast cancer is the most common type of cancer diagnosed in women and is a significant cause of morbidity and mortality. While there are many risk factors known to be associated with increased breast cancer risk, this review will focus specifically on circulating IGF-I, hyperinsulinemia, and type 2 diabetes. Their effects on promoting breast cancer development, progression, and adverse outcomes have been demonstrated in both animal and human studies, suggesting that the IGF system is a potential target for breast cancer therapy. In addition, in the clinical setting, emphasizing metabolic risk modifications to patients including weight loss, dietary changes, and diabetes control may also play an important role in breast cancer risk reduction.

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Abbreviations

IGF:

insulin-like growth factor

IGFBP:

insulin-like growth factor binding protein

BMI:

body mass index

IGF-IR:

insulin-like growth factor-I receptor

IR:

insulin receptor

IRS:

insulin receptor substrate

PI3K:

phosphatidylinositol 3-kinase

MAPK:

mitogen-activated protein kinase

ER:

estrogen receptor

TEB:

terminal end bud

GH:

growth hormone

GHRH:

growth hormone releasing hormone

JAK:

janus kinase

STAT:

signal transducer and activator of transcription

ALS:

acid labile subunit

MMTV:

mouse mammary tumor virus

SDR:

spontaneous dwarf rat

LID:

Liver IGF-I Deficient

DMBA:

7,12-dimethylbenz(a)anthracene

SV40-LTA:

SV40 large T antigen

SHBG:

sex hormone binding globulin

MCK:

muscle creatine kinase

PyVmT:

polyoma virus middle T antigen

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Correspondence to Derek LeRoith.

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Dr. Derek LeRoith is presently a consultant and speaker and receives as honorarium from Merck, Sanofi-Aventis, Pfizer, Takeda, and Novo Nordisk.

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Lann, D., LeRoith, D. The Role of Endocrine Insulin-Like Growth Factor-I and Insulin in Breast Cancer. J Mammary Gland Biol Neoplasia 13, 371–379 (2008). https://doi.org/10.1007/s10911-008-9100-x

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  • Issue Date:

  • DOI: https://doi.org/10.1007/s10911-008-9100-x

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